Organovo. has patented a method for fabricating three-dimensional biological tissues using bioprinting. The process involves preparing a bio-ink with living cells, extruding it to form a structure, and subjecting it to specific low-temperature conditions for optimal tissue development. GlobalData’s report on Organovo gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Organovo, 3D Bioprinting was a key innovation area identified from patents. Organovo's grant share as of July 2024 was 38%. Grant share is based on the ratio of number of grants to total number of patents.
Methods for fabricating three-dimensional biological tissues using bioprinting
The granted patent US12037603B2 outlines a method for fabricating three-dimensional engineered biological tissues using a bio-ink composed of living cells. The process involves several key steps: preparing the bio-ink, which can be in a viscous liquid, semi-solid, or solid form; depositing the bio-ink onto a surface through extrusion bioprinting; and subjecting the bio-ink to a hypothermic hold at temperatures between 2°C and 10°C. Following this, the bio-ink is incubated at a temperature ranging from 18°C to 37°C. Notably, the method emphasizes that the bio-ink should not be exposed to any ionic, chemical, photo, or physical cross-linkers during the hypothermic hold, which is limited to a maximum of 60 minutes.
Additionally, the patent claims that this method reduces apoptosis in the bioprinted tissue compared to tissues fabricated through other methods. The bio-ink can consist of a single human cell type or a combination, such as renal fibroblasts and human umbilical vein endothelial cells (HUVECs). The method also allows for the inclusion of test substances to evaluate their effects on the engineered tissue. Importantly, the resulting biological tissue is free of pre-formed scaffolds, further distinguishing this fabrication technique. The claims provide a comprehensive framework for producing viable biological tissues with potential applications in regenerative medicine and tissue engineering.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
