ORM-5029 is under clinical development by Orum Therapeutics and currently in Phase I for Human Epidermal Growth Factor Receptor 2 Positive Breast Cancer (HER2+ Breast Cancer). According to GlobalData, Phase I drugs for Human Epidermal Growth Factor Receptor 2 Positive Breast Cancer (HER2+ Breast Cancer) have an 86% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how ORM-5029’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

ORM-5029 overview

ORM-5029 is under development for the treatment of solid tumor and HER2-expressing breast cancer such as HER2+ breast cancer. It is an antibody neoDegrader conjugate (AnDC) and being developed based on OromabTM, a cell-specific, cell-penetrating antibody platform technology. It is administered through intravenous route. It acts by targeting HER2 and HER3.

Orum Therapeutics overview

Orum Therapeutics, Inc., a biotechnology company that develops a new class of therapeutic antibodies targeting cytosolic proteins for unmet medical needs in cancer. The company is headquartered in Republic of Korea (South Korea).

For a complete picture of ORM-5029’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.