PBCMAALLO-1 is under clinical development by Poseida Therapeutics and currently in Phase I for Refractory Multiple Myeloma. According to GlobalData, Phase I drugs for Refractory Multiple Myeloma have a 78% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how PBCMAALLO-1’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
P-BCMA-ALL-O1 is under development for the treatment of relapsed and refractory multiple myeloma. It is administered intravenously. It comprises of allogeneic CAR-T cells, developed based on Piggybac DNA modification system, NextGEN CRISPR site-specific nuclease platform. The drug candidate acts by targeting B-cell maturation antigen (BCMA).
Poseida Therapeutics overview
Poseida Therapeutics is a biopharmaceutical company. It harnesses its proprietary gene engineering platform, to develop next generation cell and gene therapeutics to treat solid tumors and hematological malignancies. The company is investigating its lead product candidate P-BCMA-101, an autologous CAR-T therapy against refractory multiple myeloma. It is also evaluating P-PSMA-101 and P-PSMA-ALL01, allogeneic chimeric antigen receptors for the treatment of prostate cancer; and Dual car (CD19/CD20) targeting solid tumor. Poseida Therapeutics is headquartered in San Diego, California, the US.
For a complete picture of PBCMAALLO-1’s drug-specific PTSR and LoA scores, buy the report here.