PEP-010 is under clinical development by PEP-Therapy and currently in Phase I for Pancreatic Ductal Adenocarcinoma. According to GlobalData, Phase I drugs for Pancreatic Ductal Adenocarcinoma does not have sufficient historical data to build an indication benchmark PTSR for Phase I. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the PEP-010 LoA Report. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
PEP-010 overview
PEP-010 (DPTC-9h) is under development for the treatment of metastatic solid tumors including triple negative breast cancer, platinum resistant metastatic ovarian cancer and pancreatic ductal adenocarcinoma. The drug candidate is a recombinant peptide (30 amino acids) constituting two sequences, DPT as a penetrating peptide and PEP1 as the interfering active peptide. It acts by targeting protein phosphatase 2A (PP2A). It is developed based on cell penetrating and interfering peptides (CP and IP) technology. It is administered through intravenous route. It was also under development for chronic lymphocytic leukemia (CLL) and lung cancer.
PEP-Therapy overview
PEP-Therapy is a medical biotechnology company that develops targeted therapies for treatment of types of cancers. The company develops cell penetrating and interfering peptides for the intracellular delivery of targeted therapies. Its pipeline products include PEP-010 with a penetrating shuttle to deliver the active peptide into the cell, and an interfering active peptide blocking Caspase-9/PP2A interaction. The company’s product is used for the treatment of triple-negative breast cancer, lung and ovary cancers, and chronic lymphocytic leukemia. It also conducts clinical trials and licenses the novel therapeutic products and companion biomarkers to both pharmaceutical and biotech companies for their development and commercialization. PEP-Therapy is headquartered in Paris, France.
For a complete picture of PEP-010’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
