PeptiDream. has been granted a patent for a method of peptide production involving the condensation of C-protected amino acids or peptides to N-protected counterparts, followed by the removal of protective groups. This process aims to enhance peptide synthesis efficiency. GlobalData’s report on PeptiDream gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on PeptiDream, Cyclosporin derivatives was a key innovation area identified from patents. PeptiDream's grant share as of June 2024 was 15%. Grant share is based on the ratio of number of grants to total number of patents.
The granted patent US11993629B2 outlines a method for producing peptides through a series of defined steps. The process begins with the condensation of a C-protected amino acid or peptide to the C-terminal of an N-protected amino acid or peptide. This initial step is followed by optional repetitions of further condensation and deprotection steps, allowing for the sequential addition of amino acids or peptides. The method also includes purification steps, which can involve liquid separation using either acidic or basic aqueous solutions. The protective groups used in the process can vary, including C1-6 alkyl groups, tri-C1-6 alkylsilyl groups, and specific fluorine compounds for deprotection.
Additionally, the patent specifies various agents and conditions for the condensation and deprotection processes. Condensation agents may include carbodiimide-based, chloroformate-based, and phosphonium-based agents, among others. The deprotection conditions can utilize water, bases, acids, or hydrogen with metal catalysts. The patent further details the structural characteristics of the protective groups, including the total number of carbon atoms in the R1R2R3Si group and the types of aliphatic hydrocarbon groups that can be employed. Overall, the claims provide a comprehensive framework for peptide synthesis, emphasizing the versatility and specificity of the chemical groups and conditions involved in the process.
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