Poziotinib hydrochloride is a Small Molecule owned by Hanmi Pharmaceuticals, and is involved in 15 clinical trials, of which 9 were completed, 5 are ongoing, and 1 is planned.
Poziotinib is a pan-HER inhibitor. HM781-36B irreversibly inhibits EGFR (HER1 or ErbB1) including EGFR mutants, HER2 exon 20 mutation and HER4, thereby inhibiting the proliferation of tumor cells that over express these receptors. EGFRs, cell surface receptor tyrosine kinases, are often up regulated in a variety of cancer cell types and play key roles in cellular proliferation and survival.
The revenue for Poziotinib hydrochloride is expected to reach a total of $3.2bn through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. View the complete picture with the Poziotinib hydrochloride NPV Report.
Poziotinib hydrochloride Overview
Poziotinib (HM781-36B) is under development for the treatment of lung adenocarcinoma, esophageal cancer, HER2 exon 20–mutated non-small cell lung cancer and metastatic breast cancer (Her2-positive) and (Her2-negative). The drug candidate is administered orally as a tablet. It is a quinazoline-based irreversible pan-HER inhibitor with Exon 20 insertions. The drug candidate is based on the NCE (new chemical entities) discovery technology platform. It was also under development for gastric cancer including gastroesophageal junction adenocarcinoma, colorectal cancer, high-grade glioma, recurrent head and neck squamous cell carcinoma.
Spectrum Pharmaceuticals Overview
Spectrum Pharmaceuticals (Spectrum) is a biopharma company that acquires, develops, and commercializes novel drug candidates for treatment of cancer. The company’s pipeline products include ROLONTIS, for treatment of chemotherapy-induced neutropenia helps to reduce the frequency of multiplication of tumors. This product is in phase 3 trails.; Poziotinib, an irreversible tyrosine kinase inhibitor, for non-small cell lung cancer (NSCLC) tumors with various mutations. This product is in phase 2 trials and lead candidate for the organization. The company has R&D facilities in, Massachusetts and California, the US. The company operates in the US, Europe, Japan, and other countries. Spectrum is headquartered in Henderson, Nevada, the US.
The operating loss of the company was US$147.7 million in FY2021, compared to an operating loss of US$169.7 million in FY2020. The net loss of the company was US$158.6 million in FY2021, compared to a net loss of US$160.9 million in FY2020.
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