Precigen. has been granted a patent for genetically modified methanotrophs that convert methane into 1,4-butanediol (1,4-BDO). The patent details the specific genetic modifications and methods for producing these microorganisms, which enhance the efficiency of chemical production from carbon substrates. GlobalData’s report on Precigen gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Precigen, Cancer treatment biomarkers was a key innovation area identified from patents. Precigen's grant share as of June 2024 was 44%. Grant share is based on the ratio of number of grants to total number of patents.
Genetically modified methanotrophs producing 1,4-butanediol from methane
The patent US12018310B2 describes a genetically modified methanotroph engineered to convert single carbon-containing hydrocarbon molecules into 1,4-butanediol. This methanotroph incorporates several heterologous genes that encode specific enzymes, including a-ketoglutarate decarboxylase, 4-hydroxybutyrate dehydrogenase, 4-hydroxybutyrate CoA transferase, aldehyde dehydrogenase, and alcohol dehydrogenase, with each enzyme exhibiting at least 90% amino acid sequence identity to designated sequences (SEQ ID NOs). The patent also outlines methods for producing this genetically modified organism, which may include the overexpression of at least one of the heterologous genes and the potential addition of fumarate hydratase or fumarate reductase.
Additionally, the patent details methods for synthesizing 1,4-butanediol by utilizing the modified methanotroph, particularly through the growth of the organism in the presence of methane or other single carbon-containing hydrocarbons. The process may be enhanced by the introduction of exogenous compounds such as gamma-hydroxybutyrate, a-ketoglutarate, or succinate. The patent further explores subsequent chemical transformations of 1,4-butanediol, including reactions with catalysts to produce tetrahydrofuran, polyurethanes, or polybutylene terephthalate, thereby expanding the potential applications of the genetically modified methanotroph in biotechnological and industrial processes.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
