Precigen has patented a splice control module for sex-specific gene expression in insects. The module utilizes a dsx-based system to induce lethality in female insects while sparing males. The invention aims to control insect populations effectively. GlobalData’s report on Precigen gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Precigen, Cancer treatment biomarkers was a key innovation area identified from patents. Precigen's grant share as of January 2024 was 43%. Grant share is based on the ratio of number of grants to total number of patents.

Splice control module for sex-specific gene expression in insects

Source: United States Patent and Trademark Office (USPTO). Credit: Precigen Inc

A recently granted patent (Publication Number: US11827876B2) discloses a doublesex (dsx) splice control module derived from Aedes aegypti. The module includes specific components such as exon 4, truncated intron 4, exon 5a, intron 5, modified exon 5b, truncated intron 6, and a fragment of exon 6 of dsx. The modified exon 5b is altered to create an open reading frame for the entire exon, allowing for sex-specific splicing when introduced into insects, particularly Diptera species like Ceratitis capitata and Aedes aegypti.

Furthermore, the patent describes a polynucleotide incorporating the dsx splice control module linked to a sequence encoding a lethal, deleterious, or sterilizing heterologous protein for insects. The heterologous protein can be tTAV, tTAV2, tTAV3, or other proteins like apoptosis-inducing factors. The polynucleotide may also include a ubiquitin Fusion Leader Polypeptide and regulatory elements like a promoter operable in insects and a tetracycline-responsive operator. Additionally, the polynucleotide may contain untranslated regions like a Drosophila melanogaster minimal HSP70 promoter and an SV40 3'UTR. An expression vector plasmid comprising this polynucleotide is also part of the patent's claims, showcasing a comprehensive approach to insect control through genetic manipulation.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies