Protagonist Therapeutics has been granted a patent for peptide inhibitors of the interleukin-23 receptor, which can be used to treat inflammatory bowel disease and other disorders. The pharmaceutical composition includes the peptide inhibitor and a carrier. GlobalData’s report on Protagonist Therapeutics gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Protagonist Therapeutics, Cyclosporin derivatives was a key innovation area identified from patents. Protagonist Therapeutics's grant share as of January 2024 was 23%. Grant share is based on the ratio of number of grants to total number of patents.

Peptide inhibitors for treating inflammatory bowel disease

Source: United States Patent and Trademark Office (USPTO). Credit: Protagonist Therapeutics Inc

A recently granted patent (Publication Number: US11884748B2) discloses a pharmaceutical composition comprising a peptide inhibitor of an interleukin-23 receptor, along with a pharmaceutically acceptable carrier, excipient, or diluent. The peptide inhibitor of the interleukin-23 receptor is specifically identified as Ac-[Abu]-QTWQC-[Phe[4-(2-aminoethoxy)]]-[2-Nal]-[Aib]-[Lys(Ac)]-NA-NH2 (SEQ ID NO:880) or a pharmaceutically acceptable salt thereof, as outlined in the claims.

The patent further details the specific peptide inhibitor sequences that can be used in the pharmaceutical composition, providing a comprehensive list of potential options for the peptide inhibitor of an interleukin-23 receptor. These sequences include Ac-[Abu]-QTWQC-[Phe[4-(2-(acetyl-aminoethoxy)]]-[2-Nal]-[a-Me-Lys(Ac)]-[Lys(Ac)]-NG-NH2 (SEQ ID NO:900) among others. The composition aims to target the interleukin-23 receptor, highlighting the potential for therapeutic applications in conditions where modulation of this receptor is beneficial. This patent underscores the innovative approach to utilizing peptide inhibitors for targeting specific receptors, potentially opening new avenues for drug development and treatment strategies in the pharmaceutical industry.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies