RedHill Biopharma has been granted a patent for a method to prepare monodisperse oligo(ethylene glycol) reagent compositions. The process involves reacting halo-terminated and hydroxyl-terminated oligomers to create specific oligo(ethylene glycol) structures, enhancing the precision of oligomer synthesis. GlobalData’s report on RedHill Biopharma gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on RedHill Biopharma, Human telomerase RT biomarker was a key innovation area identified from patents. RedHill Biopharma's grant share as of July 2024 was 57%. Grant share is based on the ratio of number of grants to total number of patents.
Method for preparing monodisperse oligo(ethylene glycol) compositions
The patent US12016952B2 outlines a method for preparing a monodisperse oligo(ethylene glycol) reagent composition through a series of chemical reactions. The process begins with the reaction of a halo-terminated oligo(ethylene glycol) with a hydroxyl-terminated oligo(ethylene glycol) to form a new oligo(ethylene glycol) with a combined number of monomer subunits. This initial reaction is conducted under specific conditions that facilitate the displacement of the halo group, utilizing a 1:1 molar ratio of the reactants. The method further involves converting the terminal hydroxyl group of the resulting oligo(ethylene glycol) into a halo group, followed by a second reaction with another hydroxyl-terminated oligo(ethylene glycol) to yield a final product with an increased number of monomer subunits. The patent specifies that the values of the monomer subunits (m and n) can range from 1 to 6.
Additionally, the claims detail various conditions and components that can enhance the reaction process. For instance, the use of a strong base, such as sodium or potassium hydride, is recommended during the reactions. The method can be performed in an organic solvent at temperatures between 0° C and 80° C, with bromo as a preferred halo group. The final product can be purified through chromatography, and there is an option to convert the hydroxyl terminus of the oligo(ethylene glycol) into an active group for further coupling with small molecules, with examples including aldehydes and activated carboxylic esters. This patent presents a systematic approach to synthesizing oligo(ethylene glycol) compounds with potential applications in various fields, including biochemistry and materials science.
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