Ribociclib succinate is a Small Molecule owned by Novartis, and is involved in 93 clinical trials, of which 32 were completed, 58 are ongoing, and 3 are planned.

Ribociclib (LEE011) inhibits the activity of an enzyme CDK4/6. CDK4 is important in both normal and cancerous cells, LEE011 decreases the ability of the bone marrow to make white blood cells, platelets, and red blood cells. Although these effects are expected to be reversible, they can increase the risk of infection, bleeding and fatigue. CDK4/6 is involved in the process that allows both normal and cancer cells to divide and multiply. Cancer cells are often driven to divide and multiply by abnormalities that increase the activity of CDK4.

The revenue for Ribociclib succinate is expected to reach a total of $24.9bn through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. View the complete picture with the Ribociclib succinate NPV Report.

Ribociclib succinate was originated by Novartis and Astex Pharmaceuticals and is currently owned by Novartis.

Ribociclib succinate Overview

Ribociclib succinate (Kisqali, Kryxana) is an antineoplastic agent. It is formulated as film coated tablets for oral route of administration. Ribociclib succinate in combination with an aromatase inhibitor as initial endocrine-based therapy for the treatment of postmenopausal women with hormone receptor positive and HER2 negative advanced or metastatic breast cancer.

Ribociclib succinate is under development for the treatment of hepatocellular carcinoma, endometrial carcinoma (third line therapy), metastatic castrate resistant prostate cancer, lymphoma, malignant rhabdoid tumors, teratoma, recurrent glioblastome multiforme or glioma, ovarian cancer, recurrent head and neck cancer squamous cell carcinoma, metastatic triple-negative breast cancer, peritoneal cancer, ALK-positive non-small cell lung cancer, neuroblastoma,  advanced or metastatic BRAF V600 mutant melanoma, well differentiated and dedifferentiated liposarcomas, mantle cell lymphomas, head and neck cancers, metastatic adenocarcinoma of the pancreas, diffuse intrinsic pontine glioma, high grade glioma, metastatic KRAS-mutant colorectal cancer, well differentiated neuroendocrine tumors of foregut origin such as thymic carcinoma, bronchopulmonary cancer, gastric cancer, duodenal cancer, relapsed and refractory acute lymphocytic leukemia, medulloblastoma, atypical teratoid rhabdoid tumor, malignant rhabdoid tumor, rhabdomyosarcoma, medulloblastoma, anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic pleomorphic xanthoastrocytoma. Ribociclib in combination with PDR001 is under development for the treatment of metastatic hormone receptor positive breast cancer and metastatic ovarian cancer. It is under development for the treatment of women with hormone receptor positive and HER2 negative locally advanced or metastatic breast cancer in combination with fulvestrant as in women who have received prior endocrine therapy. It was under development for the treatment of teratoma. It was under development for the treatment of teratoma.

Novartis Overview

Novartis is a healthcare company that focuses on the discovery, development, manufacture and marketing of prescription and generic pharmaceutical products and eye care products. It provides drugs for the treatment of cancer, cardiovascular diseases, dermatological conditions, neurological disorders, ophthalmic and respiratory diseases, immune disorders, and infections, among others. The company offers generic medicines and biosimilars through Sandoz. Novartis conducts research in various disease areas through The Novartis Institutes for BioMedical Research (NIBR). The company operates through a network of subsidiaries and offices across the Americas, Europe, the Middle East, Africa, and Asia-Pacific. Novartis is headquartered in Basel, Switzerland.

The company reported revenues of (US Dollars) US$52,877 million for the fiscal year ended December 2021 (FY2021), an increase of 6% over FY2020. In FY2021, the company’s operating margin was 22.1%, compared to an operating margin of 20.3% in FY2020. In FY2021, the company recorded a net margin of 45.4%, compared to a net margin of 16.2% in FY2020. The company reported revenues of US$12,842 million for the third quarter ended September 2022, a decrease of 1.9% over the previous quarter.

Quick View – Ribociclib succinate

Report Segments
  • Innovator (NME)
Drug Name
  • Ribociclib succinate
Administration Pathway
  • Oral
Therapeutic Areas
  • Oncology
Key Companies
Highest Development Stage
  • Marketed

GlobalData

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.