Ribociclib succinate is under clinical development by Novartis and currently in Phase I for Pediatric Diffuse Intrinsic Pontine Glioma. According to GlobalData, Phase I drugs for Pediatric Diffuse Intrinsic Pontine Glioma does not have sufficient historical data to build an indication benchmark PTSR for Phase I. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the Ribociclib succinate LoA Report. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Ribociclib succinate overview
Ribociclib succinate (Kisqali, Kryxana) is an antineoplastic agent. It is formulated as film coated tablets for oral route of administration. Ribociclib succinate in combination with an aromatase inhibitor as initial endocrine-based therapy for the treatment of postmenopausal women with hormone receptor positive and HER2 negative advanced or metastatic breast cancer.
Ribociclib succinate is under development for the treatment of hepatocellular carcinoma, endometrial carcinoma (third line therapy), metastatic castrate resistant prostate cancer, lymphoma, malignant rhabdoid tumors, teratoma, recurrent glioblastome multiforme or glioma, ovarian cancer, recurrent head and neck cancer squamous cell carcinoma, metastatic triple-negative breast cancer, peritoneal cancer, ALK-positive non-small cell lung cancer, neuroblastoma, advanced or metastatic BRAF V600 mutant melanoma, well differentiated and dedifferentiated liposarcomas, mantle cell lymphomas, head and neck cancers, metastatic adenocarcinoma of the pancreas, diffuse intrinsic pontine glioma, high grade glioma, metastatic KRAS-mutant colorectal cancer, well differentiated neuroendocrine tumors of foregut origin such as thymic carcinoma, bronchopulmonary cancer, gastric cancer, duodenal cancer, relapsed and refractory acute lymphocytic leukemia, medulloblastoma, atypical teratoid rhabdoid tumor, malignant rhabdoid tumor, rhabdomyosarcoma, medulloblastoma, anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic pleomorphic xanthoastrocytoma. Ribociclib in combination with PDR001 is under development for the treatment of metastatic hormone receptor positive breast cancer and metastatic ovarian cancer. It is under development for the treatment of women with hormone receptor positive and HER2 negative locally advanced or metastatic breast cancer in combination with fulvestrant as in women who have received prior endocrine therapy. It was under development for the treatment of teratoma. It was under development for the treatment of teratoma.
Novartis is a healthcare company that focuses on the discovery, development, manufacture and marketing of prescription and generic pharmaceutical products and eye care products. It provides drugs for the treatment of cancer, cardiovascular diseases, dermatological conditions, neurological disorders, ophthalmic and respiratory diseases, hematologic diseases, solid tumors, immune disorders, and infections, among others. The company offers generic medicines and biosimilars through Sandoz. Novartis conducts research in various disease areas through The Novartis Institutes for BioMedical Research (NIBR). The company operates through a network of subsidiaries and offices across the Americas, Europe, the Middle East, Africa, and Asia-Pacific. Novartis is headquartered in Basel, Switzerland.
For a complete picture of Ribociclib succinate’s drug-specific PTSR and LoA scores, buy the report here.