Selinexor is a Small Molecule owned by Karyopharm Therapeutics, and is involved in 96 clinical trials, of which 39 were completed, 50 are ongoing, and 7 are planned.

Selinexor is a selective inhibitor of nuclear export. It inhibits CRM1 (chromosome region maintenance 1 protein, exportin 1 or XPO1). CRM1, the major export factor for proteins from the nucleus to the cytoplasm, is over-expressed in a variety of cancer cell types. The export protein CRM1 is required for the nuclear export of a wide variety of cancer-related cargo proteins including p53 (a tumor suppressor protein), c-Abl, (a protein tyrosine kinase), and FOXO-3A (this protein is likely to function as a trigger for apoptosis). CRM1 recognizes its cargo proteins through their leucine-rich nuclear export sequence. The CRM1-cargo complex is then actively transported across the nuclear pore complex to the cytoplasm where the cargo is released after RanGAP-catalyzed GTP hydrolysis. RanGAP is a protein involved in the transport of other proteins from the cytosol to the nucleus in eukaryotic cells.

The revenue for Selinexor is expected to reach a total of $8.6bn through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. View the complete picture with the Selinexor NPV Report.

Selinexor was originated by Rega Institute for Medical Research and Karyopharm Therapeutics and is currently owned by Karyopharm Therapeutics. Antengene is the other company associated in development or marketing of Selinexor.

Selinexor Overview

Selinexor (Xpovio, Nexpovio) is an antineoplastic agent. It is formulated as film coated tablets for oral route of administration. Xpovio in combination with dexamethasone is indicated for the treatment of adult patients with relapsed or refractory multiple myeloma (RRMM) who have received at least four prior therapies and whose disease is refractory to at least two proteasome inhibitors, at least two immunomodulatory agents, and an anti-CD38 monoclonal antibody. Xpovio is indicated for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), not otherwise specified, including DLBCL arising from follicular lymphoma, after at least 2 lines of systemic therapy. Xpovio in combination with bortezomib and dexamethasone is indicated for the treatment of adult patients with multiple myeloma who have received at least one prior therapy.

Selinexor (KPT-330) is under development for the treatment of light chain amyloidosis, anaplastic astrocytoma, diffuse intrinsic pontine glioma (DIPG), high-grade glioma (HGG), newly diagnosed advanced hepatocellular carcinoma, metastatic urothelial carcinoma, relapsed or refractory peripheral T cell lymphoma and natural killer T cell lymphomas,  relapsed/refractory indolent non-Hodgkin lymphoma (R/R iHNL), malignant peripheral nerve sheath tumor (MPNST), leiomyosarcoma, endometrial stromal sarcoma, ovarian carcinoma, endometrial carcinoma, fallopian tube cancer, metastatic triple negative breast cancer, thymoma, non-small cell lung cancer, cervical carcinoma, non-Hodgkin lymphoma, melanoma, colon cancer, gastroenteropancreatic tumors, prolymphocytic leukemia, small lymphocytic lymphoma, recurrent glioblastoma, follicular lymphoma, mantle cell lymphoma, chronic lymphocytic leukemia (CLL), relapsed/refractory multiple myeloma (MM), relapsed and refractory acute myelogenous leukemia (AML), diffuse large B-cell lymphoma, chondrosarcoma, synovial sarcoma, liposarcoma, leiomyosarcoma, blast-crisis chronic myelogenous leukemia (bc-CML), relapsed and refractory acute lymphoblastic leukemia, rectal cancer, lung cancer, gynecological cancer, Penta-refractory multiple myeloma, recurrent/refractory high-grade gliomas, myelofibrosis, primary myelofibrosis, Post-Polycythemia Vera Myelofibrosis, Post-Essential Thrombocythemia Myelofibrosis (Post-ET MF), Ewing sarcoma and myelodysplastic syndrome, gastrointestinal stromal tumor (GIST), non-small cell lung cancer and recurrent glioma. The drug candidate is administered orally as a tablet and topically as a gel. It is a SINE compound that acts by targeting CRM1 (chromosome region maintenance 1 protein, exportin 1 or XPO1).

It was also under development for the treatment of coronavirus disease 2019 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), refractory or relapsed Richter's transformation, metastatic castrate-resistant prostate cancer, advanced squamous cell carcinoma of head and neck, lung cancer and esophageal cancer, relapsed/refractory cutaneous T cell lymphoma, relapsed small cell lung cancer, rectal adenocarcinoma, gastric cancer, metastatic colorectal cancer and diabetic foot ulcers.

It was also under development for the treatment of recurrent glioblastoma multiforme.

Antengene Overview

Antengene is a biopharmaceutical company that discovers and develops oncology medicines. The company is investigating ATG-010, a first-in-class SINE compound targeting XPO1 molecule, to treat multiple myeloma and diffuse large B-cell lymphoma; ATG-008, an mTOR kinase inhibitor for the treatment of solid tumors and hematological malignancies; ATG-016 targeting KRAS-mutant solid tumors and nasopharyngeal carcinoma; ATG-527 against viral infection; ATG-019, oral inhibitor for solid tumors; ATG-017, signal- regulated kinases 1 and 2 (ERK1/2) inhibitor solid tumors, non-Hodgkin lymphoma, acute myeloid leukemia. It is also evaluating drugs against solid tumors, hematology, and oncology indications. The company has additional office in Shaoxing, Zhejiang, China; and operational presence in Hong Kong and the US. Antengene is headquartered in Shanghai, China.

The company reported revenues of (Renminbi) CNY28.8 million for the fiscal year ended December 2021 (FY2021). The operating loss of the company was CNY654.8 million in FY2021, compared to an operating loss of CNY2,927.9 million in FY2020. The net loss of the company was CNY655.5 million in FY2021, compared to a net loss of CNY2,928.9 million in FY2020.

Quick View – Selinexor

Report Segments
  • Innovator (NME)
Drug Name
  • Selinexor
Administration Pathway
  • Oral
  • Topical
Therapeutic Areas
  • Infectious Disease
  • Metabolic Disorders
  • Oncology
Key Companies
Highest Development Stage
  • Marketed

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, potential applicable patients, drug margins, company expenses, and pricing estimates. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate rNPV, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA)and phase transition success rate(PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.