SGNB-6A is under clinical development by Seagen and currently in Phase I for Adenocarcinoma Of The Gastroesophageal Junction. According to GlobalData, Phase I drugs for Adenocarcinoma Of The Gastroesophageal Junction have an 88% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how SGNB-6A’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
SGNB-6A is under development for the treatment of solid tumors including non-small cell lung cancer (NSCLC), adenocarcinoma of the gastroesophageal junction, head and neck squamous cell cancer (HNSCC), HER2 negative breast cancer, esophageal squamous cell carcinoma, ovarian cancer, cutaneous squamous cell cancer (SCC), exocrine pancreatic adenocarcinoma, bladder cancer, cervical cancer and gastric cancer. It is administered through intravenous route. It is an vedotin-based ADC. The drug candidate comprises monoclonal antibody conjugated with monomethyl auristatin E (MMAE). It acts by targeting integrin beta 6.
Seagen, formerly Seattle Genetics, is a biotechnology company that discovers, develops, and markets monoclonal antibody-based therapies for the treatment of cancer. It markets antibody-drug conjugates (ADCs), including Adcetris (brentuximab vedotin), for the treatment of Hodgkin’s lymphoma, T-cell lymphomas and CD30-expressing lymphomas; Padcevtm (enfortumab vedotin-ejfv) for metastatic urothelial cancers; Tukysa (tucatinib) for the treatment of metastatic HER2-positive breast cancers, and Tivdak (tisotumab vedotin-tftv) for the treatment of certain metastatic cervical cancers. The company’s pipeline consists of novel therapies for addressing the unmet medical needs of blood-related cancers and solid tumors. Seagen products and pipeline are based on ADC technology, which targets monoclonal antibodies and delivers agents for killing cancer cells. The company sells its products through specialty distributors. Seagen is headquartered in Bothell, Washington, the US.
For a complete picture of SGNB-6A’s drug-specific PTSR and LoA scores, buy the report here.