Singular Genomics Systems has been granted a patent for modified Archaeal family B polymerases from Pyrococcus microorganisms, enhancing nucleotide analogue incorporation in DNA sequencing. The polymerase must contain specific amino acid sequences outlined in the claim for improved functionality. GlobalData’s report on Singular Genomics Systems gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Singular Genomics Systems, DNA polymerase compositions was a key innovation area identified from patents. Singular Genomics Systems's grant share as of January 2024 was 24%. Grant share is based on the ratio of number of grants to total number of patents.

Modified archaeal polymerases for improved dna sequencing

Source: United States Patent and Trademark Office (USPTO). Credit: Singular Genomics Systems Inc

A recently granted patent (Publication Number: US11884943B2) discloses a novel polymerase with specific amino acid sequences that enhance its ability to incorporate modified nucleotides into nucleic acid sequences. The polymerase described in the patent comprises amino acid sequences that are highly similar to specific sequences within SEQ ID NO: 1, with key amino acids at positions 409, 410, and 93 playing a crucial role in its function. Additionally, the polymerase exhibits increased efficiency in incorporating modified nucleotides compared to standard polymerases, making it a valuable tool for various molecular biology applications.

Furthermore, the patent covers a wide range of polymerase variants derived from various Pyrococcus species, capable of functioning across a broad temperature range from 40°C to 80°C. These polymerases can be used in methods for incorporating modified nucleotides into nucleic acid sequences under stringent conditions, making them suitable for applications such as sequencing nucleic acid sequences. The patent also includes kits containing the novel polymerase, providing researchers with a convenient tool for enhancing nucleic acid sequencing and other molecular biology techniques. Overall, the patented polymerase variants offer promising advancements in the field of molecular biology, particularly in the development of more efficient and versatile tools for genetic analysis and manipulation.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies