SP-16 is under clinical development by Serpin Pharma and currently in Phase II for Myocardial Infarction. According to GlobalData, Phase II drugs for Myocardial Infarction have a 45% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how SP-16’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

SP-16 overview

SP-16 is under development for the treatment of type 1 diabetes, chemotherapy-induced peripheral neuropathy (CIPN), pneumonia due to SARS-CoV-2 infection and its associated ARDS, type 2 diabetes, myocardial infarction, eosinophilic esophagitis (EoE), chronic inflammatory, demyelinating neuropathy (CIDN), pemphigus vulgaris, acute kidney injury, atopic dermatitis and alopecia areata. The drug candidate is a serpin short peptide, derived from human alpha-1-antitrypsin. The drug candidate is administered through subcutaneous route. It acts by targeting toll-like receptor 2 (TLR-2) and low density lipoprotein receptor related protein 1.

Serpin Pharma overview

Serpin Pharma is the US-based pharmaceutical company that discovers and develops medicines for the treatment of diabetes, systematic inflammation and orphan diseases. Its lead indication includes heart attack or Acute myocardial infarction (AMI)

For a complete picture of SP-16’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.