Tavokinogene telseplasmid is under clinical development by OncoSec Medical and currently in Phase II for Metastatic Melanoma. According to GlobalData, Phase II drugs for Metastatic Melanoma have a 34% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Tavokinogene telseplasmid’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Tavokinogene telseplasmid overview

Tavokinogene telseplasmid (DNA IL-12, Interleukin-12) is under development for the treatment of metastatic melanoma and solid tumor. The drug candidate is administered through intratumoral route. The drug candidate is being developed OMS electroImmunotherapy technology that allows delivery of a DNA (nucleic acid) based cytokine coded for interleukin-12, or DNA IL-12. The therapeutic candidate targets cell-surface receptor interleukin-12. It was also under development for the treatment of solid tumors, squamous merkel cell carcinoma, mycosis fungoides, metastatic cerival cancer, cutaneous T-cell lymphoma, head and neck cancer squamous cell carcinoma and triple negative breast cancer.

OncoSec Medical overview

OncoSec Medical (OncoSec) is a biotechnology company. The company offers services to stimulate body’s immune system and attack cancer. Its lead candidate, ImmunoPulse IL-12, consists of a plasmid construct encoding the proinflammatory cytokine, IL-12, which is delivered into the tumor through in vivo electroporation. OncoSec is conducting pipeline programs for various indications which include metastatic melanoma, triple negative breast cancer and solid tumors. The company is also identifying and developing novel immune-targeting agents for use with the immunogenicity platform. It conducts pre-clinical and clinical studies targeting various cancers in collaboration with various academic medical centers and companies. OncoSec is headquartered in San Diego, California, the US

For a complete picture of Tavokinogene telseplasmid’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.