TCR-T Library is under clinical development by Alaunos Therapeutics and currently in Phase II for Lung Adenocarcinoma. According to GlobalData, Phase II drugs for Lung Adenocarcinoma does not have sufficient historical data to build an indication benchmark PTSR for Phase II. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the TCR-T Library LoA Report. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

TCR-T Library overview

Gene-modified cell therapy is under development for the treatment of solid tumors including neuroblastoma, small-cell lung cancer, gastrointestinal cancer, genitourinary cancer, metastatic colorectal cancer, non-small cell lung cancer, squamous non-small cell lung cancer, lung adenocarcinoma, non-small cell lung cancer and breast cancer, ovarian cancer, squamous non-small cell lung cancer and glioblastoma targeting KRAS, TP53 and EGFR hotspot mutations. The drug development is based on non viral integration technology platform (Sleeping Beauty Transposon/Transposase System). It is administered through parenteral and intravenous route.

It was under development for the treatment of cholangiocarcinoma, pancreatic cancer, endometrial cancer.

Alaunos Therapeutics overview

Alaunos Therapeutics formerly ZIOPHARM Oncology, is a biopharmaceutical company which provides next-generation immune therapies. The company carries out the development and commercialization of in-licensed cancer drugs. It offers controlled IL-12 which provides therapy for cold tumors by turning them hot by activating an immune response and t-cell therapy to fight blood cancers and solid tumors. Alaunos Therapeutics also offers Sleeping Beauty Technology, a clinically advanced non-viral cell therapy technology which helps in the manufacturing of genetically modified chimeric antigen receptors (CARs) and T-cell receptors (TCRs) targeting specific tumor-derived antigens. Its products and technologies are used in the treatment of hematologic malignancies, solid tumors and graft-versus-host-disease. Alaunos Therapeutics is headquartered in Boston, Massachusetts, the US.

For a complete picture of TCR-T Library’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 2 September 2023

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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.