Therapeutic Solutions International. has filed a patent for cells and cellular compositions derived from gene-edited pluripotent stem cells to treat degenerative and autoimmune diseases. The method involves inducing expression of specific factors, differentiation into regenerative cells, and potentially adding immune modulatory properties. GlobalData’s report on Therapeutic Solutions International gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Therapeutic Solutions International, Cancer immunotherapy was a key innovation area identified from patents. Therapeutic Solutions International's grant share as of January 2024 was 11%. Grant share is based on the ratio of number of grants to total number of patents.

A recently filed patent (Publication Number: US20240034996A1) outlines a method for treating degenerative conditions using pluripotent stem cells. The method involves obtaining a pluripotent stem cell, inducing expression of factors to promote differentiation into the desired cell lineage, differentiating the stem cell into a regenerative cell, optionally adding chemoattractant and immune modulatory activities to the regenerative cell. The degenerative conditions targeted include loss of function, deterioration, fibrosis, inflammation, autoimmune attack, and denervation in various organ systems.

Furthermore, the patent specifies that the pluripotent stem cell used can be an inducible pluripotent stem cell generated through dedifferentiation by introducing proteins capable of inducing dedifferentiation. The resulting cells express pluripotency markers such as TRA-1-60, hTERT, TRA-1-81, SSEA4, OCT4, and SOX2. The proteins used for inducing dedifferentiation include OCT4, NANOG, KLF-1, SOX-2, and h-RAS. This method offers a potential treatment approach for a wide range of degenerative conditions affecting various organ systems, providing a novel and promising avenue for regenerative medicine.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies