Twist Bioscience. has filed a patent for nano-scale devices enabling precise control over reaction conditions for manufacturing high-quality oligonucleotides. The invention allows rapid construction of accurate nucleic acid libraries. The claim details a device for polynucleotide synthesis with specific structural and heating unit requirements. GlobalData’s report on Twist Bioscience gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Twist Bioscience, Water gas shift catalysts was a key innovation area identified from patents. Twist Bioscience's grant share as of January 2024 was 19%. Grant share is based on the ratio of number of grants to total number of patents.

Nano-scale devices for manufacturing high-quality oligonucleotides

Source: United States Patent and Trademark Office (USPTO). Credit: Twist Bioscience Corp

A patent application (Publication Number: US20240001325A1) describes a device for polynucleotide synthesis that includes a solid support with structures for polynucleotide extension, each structure having a width of 10 nm to 1000 nm and in contact with a heating unit containing at least one electrode. The device also features a solvent distributed across the surface, with specific requirements for the polarity, melting temperature, and boiling temperature of the solvent. The device is designed to have a large number of loci for nucleic acid synthesis, ranging from at least 30,000 to 1,000,000 loci, and includes addressable electrodes for precise heating of individual loci.

Furthermore, the patent application outlines methods for polynucleotide synthesis using the described device, involving predetermined sequences for a library of polynucleotides and the synthesis of these polynucleotides extending from the surface of the substrate. The methods emphasize the importance of the solvent properties, such as melting temperature and boiling temperature, in preventing deblocking of the polynucleotides during the synthesis process. The methods also include steps for contacting the surface with nucleotide phosphoramidites and condensing or melting the solvent to facilitate the synthesis process. Overall, the patent application presents a comprehensive approach to polynucleotide synthesis using the innovative device and methods outlined in the claims.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies