The Tyrosine Protein Kinase SYK pipeline drugs market research report outlays comprehensive information on the Tyrosine Protein Kinase SYK targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA), and molecule type. GlobalData’s report assesses the drugs in the Tyrosine Protein Kinase SYK pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline. Buy the report here.
The report also covers products from therapy areas such as Immunology, Oncology, Ophthalmology, and Hematological Disorders which include the indications Rheumatoid Arthritis, Inflammation, Oncology, Acute Myelocytic Leukemia (AML, Acute Myeloblastic Leukemia), Allergic Conjunctivitis, Keratoconjunctivitis Sicca (Dry Eye), Idiopathic Thrombocytopenic Purpura (Immune Thrombocytopenic Purpura), and Acquired (Autoimmune) Hemolytic Anemia. It also reviews key players involved in Tyrosine Protein Kinase SYK targeted therapeutics development with respective active and dormant or discontinued products.
The Tyrosine Protein Kinase SYK pipeline targets constitutes close to 30 molecules. Out of which, approximately 29 molecules are developed by companies and the remaining by the universities/institutes. The molecules developed by companies in Pre-Registration, Phase II, Phase I, Preclinical, and Discovery stages are 2, 10, 1, 13, and 3 respectively. Similarly, the universities portfolio in Preclinical comprises 1 molecule.
Tyrosine Protein Kinase SYK overview
Spleen tyrosine kinase, also known as Syk, is an enzyme encoded by the SYK gene. It regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. It assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent.
For a complete picture of Tyrosine Protein Kinase SYK’s drug pipeline, buy the report here.
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