Ulevostinag is under clinical development by Merck and currently in Phase I for Hepatocellular Carcinoma. According to GlobalData, Phase I drugs for Hepatocellular Carcinoma have an 81% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how Ulevostinag’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Ulevostinag (MK-1454) is under development for the treatment of triple negative breast cancer, hepatocellular carcinoma, pancreatic cancer, colorectal cancer, anaplastic thyroid cancer, recurrent head and neck squamous cell carcinoma, head and neck squamous cell carcinoma of oral cavity, oropharynx, hypopharynx, or larynx and lymphomas including cutaneous T cell lymphoma. It is a synthetic cyclic dinucleotide. It is administered through intratumoral route. The drug candidate acts by targeting the stimulator of interferon genes (STING) protein.
Merck is a biopharmaceutical company focused on the discovery, development, manufacturing and marketing of prescription medicines, biologic therapies, vaccines and animal health products. It offers prescription products for therapy areas related to cardiovascular, cancer, immune disorders, infectious, respiratory and women’s diseases, and diabetes. The company provides animal health products such as vaccines, poultry products, livestock products and aquaculture products. Merck sells medicines to drug wholesalers, retailers, hospitals, government agencies and managed health care providers; and animal health products to veterinarians, distributors and animal producers. The company and its subsidiaries operate in the Americas, Europe, the Middle East, Africa, Asia Pacific, and Latin America. Merck is known as MSD outside the US and Canada and is headquartered in Kenilworth, New Jersey, the US.
For a complete picture of Ulevostinag’s drug-specific PTSR and LoA scores, buy the report here.