United Therapeutics has patented a method to modify polymeric scaffolds by altering their mechanical and biological properties. The method involves using specific agents to increase lung cell attachment and reduce the Young’s modulus of the scaffold. GlobalData’s report on United Therapeutics gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on United Therapeutics, Cancer treatment biomarkers was a key innovation area identified from patents. United Therapeutics's grant share as of May 2024 was 36%. Grant share is based on the ratio of number of grants to total number of patents.

Modifying polymeric scaffold to enhance lung cell attachment

Source: United States Patent and Trademark Office (USPTO). Credit: United Therapeutics Corp

A recently granted patent (Publication Number: US11986999B2) discloses a method for modifying a polymeric scaffold to enhance lung cell attachment and reduce the Young's modulus of the scaffold. The method involves contacting the polymeric scaffold with a hydrolysis agent containing NaOH and a proteolysis agent with cholesterol esterase, followed by exposure to lung cells. The modification process aims to improve the scaffold's biocompatibility and mechanical properties, potentially benefiting tissue engineering applications.

The patent claims detail various aspects of the method, including the composition of the polymeric scaffold, the concentrations and durations of the hydrolysis and proteolysis agents, and the potential inclusion of additional components like collagen and hydroxypropyl acrylate. The scaffold can be further customized with features such as channels and walls of specific dimensions to suit different tissue engineering needs. The resulting polymeric scaffold, produced through the disclosed method, demonstrates increased affinity for cells, particularly lung cells, showcasing its potential for use in regenerative medicine and other biomedical applications.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies