Valproic acid is under clinical development by Cereno Scientific and currently in Phase II for Pulmonary Arterial Hypertension. According to GlobalData, Phase II drugs for Pulmonary Arterial Hypertension have a 62% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Valproic acid’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Valproic acid overview

Valproic acid (CS-1) is under development for the treatment of thrombosis and  pulmonary arterial hypertension. It is administered through oral route as capsule. CS-1 is an enhancer of t-PA production and inhibitor of PAI-1 production. The drug candidate acts by targeting histone deacetylase (HDAC). It is a controlled release formulation of sodium valproate.

Cereno Scientific overview

Cereno Scientific is a biotechnology company. It operates as a developer of preventive drugs that normalize the body’s own defense system against blood clots. The company develops drugs in the therapeutic area of thrombosis-related cardiovascular diseases. Cereno Scientific offers pipeline products such as CS1 and NCE. Its CS1 is being developed for the treatment of fibrinolysis. CS1 increases the production of tissue plasminogen activator (t-PA) and reduces the production plasminogen activator inhibitor-1 (PAI-1) that acts as inhibitor of t-PA. Its therapy enables to only act on clots, without affecting the entire body. The company works in partnership with Galenica AB, to develop unique formulation of CS1. Cereno Scientific is headquartered in Gothenburg, Vastra Gotland, Sweden.

For a complete picture of Valproic acid’s drug-specific PTSR and LoA scores, buy the report here.

GlobalData

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.