Vidofludimus calcium is a small molecule commercialized by Immunic, with a leading Phase III program in Coronavirus Disease 2019 (COVID-19). According to Globaldata, it is involved in 14 clinical trials, of which 8 were completed, 4 are ongoing, and 2 were terminated. GlobalData uses proprietary data and analytics to provide a complete picture of Vidofludimus calcium’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
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The revenue for Vidofludimus calcium is expected to reach an annual total of $276 mn by 2035 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Vidofludimus calcium Overview
Vidofludimus calcium (IMU-838) is under development for the treatment of relapsing-remitting multiple sclerosis, progressive multiple sclerosis and coronavirus disease 2019 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primary progressive multiple sclerosis (ppms), secondary progressive multiple sclerosis (spms) and long COVID (post COVID syndrome). The drug candidate is administered by oral route. It is a calcium salt of vidofludimus. It targets dihydroorotate dehydrogenase (DHODH) andNurr1 (Nuclear receptor related 1). It was under development for the treatment of ulcerative colitis, primary sclerosing cholangitis and crohn's disease.
Immunic Overview
Immunic (Immunic Therapeutics) is a biopharmaceutical company that discovers, develops and commercializes oral immunology therapies to treat chronic inflammatory and autoimmune diseases. The company’s pipeline products include vidofludimus calcium IMU-838, a selective immune modulator for the treatment of relapsing-remitting multiple sclerosis (RRMS), progressive multiple sclerosis and moderate-to-severe ulcerative colitis. Its other pipelines include IMU-856 and IMU-381 for celiac disease, inflammatory bowel disease, short bowel syndrome and irritable bowel syndrome with diarrhea and gastrointestinal diseases. The company operates in Germany and the US. Immunic Therapeutics is headquartered in New York, the US.
The operating loss of the company was US$99.2 million in FY2023, compared to an operating loss of US$119.5 million in FY2022. The net loss of the company was US$93.6 million in FY2023, compared to a net loss of US$120.4 million in FY2022.
For a complete picture of Vidofludimus calcium’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
