Yuhan has been granted a patent for a double-stranded oligonucleotide designed to specifically inhibit amphiregulin expression. This invention includes various structural forms and nanoparticles, with potential applications in preventing or treating fibrosis and respiratory diseases. GlobalData’s report on Yuhan gives a 360-degree view of the company including its patenting strategy. Buy the report here.
Smarter leaders trust GlobalData
According to GlobalData’s company profile on Yuhan, Cancer treatment biomarkers was a key innovation area identified from patents. Yuhan's grant share as of June 2024 was 43%. Grant share is based on the ratio of number of grants to total number of patents.
Double-stranded oligonucleotide for inhibiting amphiregulin expression
The granted patent US12037589B2 outlines a series of claims related to novel compounds characterized by specific structural formulas (3) and (4). These compounds include DNA sense strands that are specific to amphiregulin, with particular sequences identified in SEQ ID NO: 1-14. The claims further detail the inclusion of RNA antisense strands that are complementary to the DNA sense strands, as well as various chemical modifications to enhance their properties. Notably, the modifications can involve substitutions at the 2' carbon position of the sugar structure in nucleotides, alterations to the sugar's oxygen, and changes to the bonds between nucleotides, including phosphorothioate and boranophosphonate bonds.
Additionally, the patent claims encompass nanoparticles that incorporate these compounds, which may consist of double-stranded oligonucleotides with unique DNA sense strand sequences. The compounds and nanoparticles are proposed for use in pharmaceutical compositions, indicating potential therapeutic applications. The claims also specify the nature of covalent bonds within the compounds, distinguishing between non-degradable and degradable bonds, and highlight the possibility of conjugating sugars or carbohydrates, such as N-acetyl galactosamine, glucose, or mannose, to enhance the functionality of the active ingredients.
To know more about GlobalData’s detailed insights on Yuhan, buy the report here.
Data Insights
From
The gold standard of business intelligence.
Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors.
GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
