Zanzalintinib is under clinical development by Exelixis and currently in Phase I for Metastatic Transitional (Urothelial) Tract Cancer. According to GlobalData, Phase I drugs for Metastatic Transitional (Urothelial) Tract Cancer have a 90% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how Zanzalintinib’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Zanzalintinib overview

Zanzalintinib (XL-092) is under development for the treatment of solid tumors such as metastatic renal cell carcinoma, metastatic urothelial carcinoma including the renal pelvis, ureter, urinary bladder, or urethra, metastatic castration resistant prostate cancer, metastatic hepatocellular carcinoma, papillary renal cell carcinoma, recurrent head and neck cancer squamous cell carcinoma, oral cavity cancer, oropharyngeal cancer, hypopharyngeal cancer, and laryngeal cancer and hormone receptor-positive breast cancer. The drug candidate is administered through oral route. It acts by targeting protein tyrosine kinases which constitutes of MET, VEGFR, AXL and MER.

It was under development for the treatment of non-small cell lung cancer.

Exelixis overview

Exelixis is a biopharmaceutical company that focuses on the development and commercialization of small molecule therapies for the treatment of cancer. The company’s marketed products include, Cometriq (cabozantinib), an inhibitor of multiple receptor tyrosine kinases; Cabometyx (cabozantinib) developed for the treatment of patients with advanced renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC). The company’s pipeline product candidates include XL092 for the treatment of advanced solid malignancies and XL888, an ATP-competitive inhibitor of HSP90, and others. The company has collaborative partnerships with biopharmaceutical companies to advance the development of potential therapies for cancer and other serious diseases. Exelixis is headquartered in Alameda, California, the US.

For a complete picture of Zanzalintinib’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.