Zevra Therapeutics has been granted a patent for a crystalline form of emetine dihydrochloride, with processes of manufacture and methods of use. GlobalData’s report on Zevra Therapeutics gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Zevra Therapeutics, Nanoparticle drug conjugates was a key innovation area identified from patents. Zevra Therapeutics's grant share as of January 2024 was 44%. Grant share is based on the ratio of number of grants to total number of patents.

Crystalline form of emetine dihydrochloride

Source: United States Patent and Trademark Office (USPTO). Credit: Zevra Therapeutics Inc

A recently granted patent (Publication Number: US11884663B2) discloses a crystalline form of Compound I dihydrochloride, characterized by specific X-ray powder diffractograms. The patent claims various forms of the crystalline compound, each with distinct peaks in their diffractograms, such as Form 2, Form 4, Form 5, and Form 6. Additionally, the patent covers pharmaceutical compositions containing the crystalline form of Compound I dihydrochloride along with a pharmaceutically acceptable carrier, and optionally, other therapeutic agents like antiparasitic agents, antibiotics, antiviral agents, and agents for controlling a cytokine storm.

Furthermore, the patent describes methods of treating viral infections, including Flavivirus infections, Zika virus, Ebola virus, coronavirus infections (such as SARS-COV-2), and diseases like COVID-19. The treatment methods involve administering the crystalline form of Compound I dihydrochloride to the subject in need, with specific mention of subjects not requiring hospitalization. The patent also highlights the use of additional therapeutic agents in combination with the crystalline form for treating viral infections, emphasizing the potential application of the disclosed compound in managing various viral diseases and conditions, including those caused by coronaviruses.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies