Zhejiang Hisun Pharmaceutical has been granted a patent for a pyrimidine derivative represented by formula (I) as a therapeutic agent, particularly as a FGFR4 kinase inhibitor. The method involves administering the compound to treat diseases related to FGFR4 over-expression. GlobalData’s report on Zhejiang Hisun Pharmaceutical gives a 360-degree view of the company including its patenting strategy. Buy the report here.
According to GlobalData’s company profile on Zhejiang Hisun Pharmaceutical, Cancer treatment biomarkers was a key innovation area identified from patents. Zhejiang Hisun Pharmaceutical's grant share as of January 2024 was 38%. Grant share is based on the ratio of number of grants to total number of patents.
Pyrimidine derivative for treating diseases of fgfr4 over-expression
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A recently granted patent (Publication Number: US11827625B2) discloses a method for treating diseases associated with FGFR4 over-expression. The method involves administering a compound represented by formula (I) or its derivatives to a patient in need of treatment. The compound can also be a specific compound of formula (II), with various substituents such as halogen or alkoxy (R1), —NHC(O)CH-CH2 (R2), and monospiroheterocyclyl (R3) that can be further substituted by alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl.
Furthermore, the patent claims cover a wide range of possible configurations for R3, including different combinations of 3-membered/6-membered, 4-membered/4-membered, 4-membered/5-membered, 4-membered/6-membered, 5-membered/5-membered, or 5-membered/6-membered monospiroheterocyclyl structures. The compound selection is not limited to a single option, providing flexibility in the choice of the compound for treatment. This patent highlights a specific method for addressing diseases related to FGFR4 over-expression, offering a potential avenue for therapeutic intervention in such conditions.
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