Formulating and Producing Tablets Containing Large, Coated Multiparticulates

Controlled-release drug delivery systems can be broadly classified as either single-unit dosage forms or multiple-unit dosage forms.

The latter are pharmaceutical formulations, in which the active pharmaceutical ingredient (API) is entrapped within or layered around a number of small, independent subunits that typically consist of spherical particles 0.05mm to 2.0mm in diameter.

Multiple dosage forms are technically more complicated, time-consuming, and expensive to produce.

However, they offer several advantages over their single-unit dosage counterparts. Many of these stem from their tendency to spread uniformly throughout the gastrointestinal tract.

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This article originally appeared in the Tablets & Capsules publication. www.tabletscapsules.com.

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