Common approaches for the scale-up of bioreactors use the gas flow coefficient (vvm) as a criterion for volumetric flow rates. Besides being the most common decisive parameter when it comes to the scaling of the gassing rate, a defined vvm is frequently used in the context of process validation, and therefore considered essential for qualification.
ZETA called the reliability of this parameter into question and evaluated the scaling competence of vvm in a study performed in the context of commissioning an upstream production plant. Based on the results of the study, ZETA strongly recommends not relying solely on this parameter, as it would certainly produce erroneous results in scaling.
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