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The Antibody Dependent Cell Mediated Cytotoxicity

The medical indications of therapeutic antibodies (tAb) have been growing. The antibody dependent cell-mediated cytotoxicity (ADCC) is a mechanism of immune defence attributed to the mode of action of several tAb, in particular, tumour cell targeting.

In ASCC, tumour cells (recognised by tAb) are targeted by natural killer cells by their FcDRlll (CD16) receptor binding to the Fc portion of the tAb followed by lysis of the target (tumour) cell.



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