View all newsletters
Receive our newsletter – data, insights and analysis delivered to you
  1. News
September 27, 2021

GeNeuro announces agreement to assess W-ENV and long-Covid syndromes

The link between W-ENV and long-Covid will be analysed to use GeNeuro’s temelimab in affected patients.

GeNeuro has signed a research agreement with Northwestern University in the US to assess the relationship between the expression of human endogenous retrovirus W envelope protein (HERV-W ENV or W-ENV) and long-Covid neuropsychiatric syndromes.

Free Report
img

Navigate your business through the ‘new normal’

COVID-19 continues to dominate headlines the world over. It has already affected our lives forever. The way we work, shop, eat, seek medical advice, and socialize will all be different in the future. Quite how different remains to be seen, but all industries must plan for multiple eventualities.  Faced with an explosion of conflicting information on how to plan and implement successful recovery strategies, decision-makers are in dire need of a single, reliable source of intelligence.   GlobalData’s COVID-19 Executive Briefing gives you access to unparalleled data and insights to successfully navigate the uncertain road to recovery across the world’s largest industries. Understand every aspect of this disruptive theme by delving into: 
  •  COVID-19 infection update, with statistics on the spread, testing by country, as well as the latest data on vaccines and therapeutic developments 
  • Economic impact overview, covering stock market indices, GDP, unemployment rates, policy responses & GlobalData’s economic recovery scorecards 
  • Sector developments, with access to sector insight summaries, cross-sector indices and the leaders and laggards in each industry vertical 
Whatever your company’s imminent strategic plans, the long-lasting impact of COVID-19 must not be overlooked. Find out how to futureproof your business operations – download our report today. 
by GlobalData
Enter your details here to receive your free Report.

The parties will analyse this link and detect affected patients who could benefit from GeNeuro’s temelimab, an anti-W-ENV antibody, the company noted.

The collaboration intends to create evidence of W-ENV expression on the transcriptional and protein level to determine if this protein can be a blood biomarker of neurological complications of long-haul Covid.

W-ENV’s pathogenic properties on neural system cells are proven and its sustained presence may offer a biological rationale and a therapeutic shift for the treatment of affected patients.

Detecting the characteristics of the patients that could benefit from temelimab therapy is a vital success factor in this latest indication.

Northwestern Medicine Neuroinfectious Diseases and Global Neurology chief professor Igor Koralnik said: “At Northwestern we are committed to finding treatments for the patients suffering from long-haul Covid‑19 and this research agreement will test an interesting hypothesis.

“We will determine whether the continued and self-sustained expression of W-ENV after the acute phase of the disease could be associated with some of the neurologic and psychiatric symptoms experienced by long-haul Covid patients.”

SARS-CoV-2 was demonstrated to induce W-ENV expression in the white blood cells of nearly 20% of healthy donors. This indicates a genetic and/or epigenetic susceptibility to produce this pathogenic protein on viral exposure.

W-ENV expression was detected in the lymphocytes of hospitalised Covid-19 patients as compared to none in healthy people.

Furthermore, the W-ENV level was linked to the severity of the evolution of the Covid-19.

The new agreement complements the efforts announced earlier in the long-haul Covid field that GeNeuro launched in Europe with Fondation FondaMental and the International Center for Infectiology Research, Lyon, France.

In March 2019, GeNeuro announced that its two-year Phase IIb study of temelimab in multiple sclerosis confirmed the results from a previous 48-week CHANGE-MS trial where the drug had a neuroprotective effect.

Related Companies

Free Report
img

Navigate your business through the ‘new normal’

COVID-19 continues to dominate headlines the world over. It has already affected our lives forever. The way we work, shop, eat, seek medical advice, and socialize will all be different in the future. Quite how different remains to be seen, but all industries must plan for multiple eventualities.  Faced with an explosion of conflicting information on how to plan and implement successful recovery strategies, decision-makers are in dire need of a single, reliable source of intelligence.   GlobalData’s COVID-19 Executive Briefing gives you access to unparalleled data and insights to successfully navigate the uncertain road to recovery across the world’s largest industries. Understand every aspect of this disruptive theme by delving into: 
  •  COVID-19 infection update, with statistics on the spread, testing by country, as well as the latest data on vaccines and therapeutic developments 
  • Economic impact overview, covering stock market indices, GDP, unemployment rates, policy responses & GlobalData’s economic recovery scorecards 
  • Sector developments, with access to sector insight summaries, cross-sector indices and the leaders and laggards in each industry vertical 
Whatever your company’s imminent strategic plans, the long-lasting impact of COVID-19 must not be overlooked. Find out how to futureproof your business operations – download our report today. 
by GlobalData
Enter your details here to receive your free Report.

Topics in this article:
NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. A weekly roundup of the latest news and analysis, sent every Friday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy
SUBSCRIBED

THANK YOU