View all newsletters
Receive our newsletter – data, insights and analysis delivered to you
  1. News
July 8, 2020

GSK partners with Medicago to develop plant-based Covid-19 vaccine

GlaxoSmithKline (GSK) has partnered with Canadian biopharmaceutical firm Medicago to develop, assess and manufacture a plant-based adjuvanted Covid-19 vaccine candidate.

GlaxoSmithKline (GSK) has partnered with Canadian biopharmaceutical firm Medicago to develop, assess and manufacture a plant-based adjuvanted Covid-19 vaccine candidate.

Free Report
img

Navigate your business through the ‘new normal’

COVID-19 continues to dominate headlines the world over. It has already affected our lives forever. The way we work, shop, eat, seek medical advice, and socialize will all be different in the future. Quite how different remains to be seen, but all industries must plan for multiple eventualities.  Faced with an explosion of conflicting information on how to plan and implement successful recovery strategies, decision-makers are in dire need of a single, reliable source of intelligence.   GlobalData’s COVID-19 Executive Briefing gives you access to unparalleled data and insights to successfully navigate the uncertain road to recovery across the world’s largest industries. Understand every aspect of this disruptive theme by delving into: 
  •  COVID-19 infection update, with statistics on the spread, testing by country, as well as the latest data on vaccines and therapeutic developments 
  • Economic impact overview, covering stock market indices, GDP, unemployment rates, policy responses & GlobalData’s economic recovery scorecards 
  • Sector developments, with access to sector insight summaries, cross-sector indices and the leaders and laggards in each industry vertical 
Whatever your company’s imminent strategic plans, the long-lasting impact of COVID-19 must not be overlooked. Find out how to futureproof your business operations – download our report today. 
by GlobalData
Enter your details here to receive your free Report.

As part of the collaboration, GSK’s pandemic adjuvant system will be combined with Medicago’s recombinant Coronavirus Virus-Like Particles (CoVLP), which mimic the novel coronavirus’ structure and enable identification by the immune system.

An adjuvant is intended to enhance the immune response and minimise the amount of antigen required per dose, facilitating the production of more vaccine doses.

In preclinical studies, Medicago’s CoVLP vaccine candidate is said to have shown a high level of neutralising antibodies when a single dose was given with adjuvant.

The company intends to begin Phase I testing this month to assess the safety and immunogenicity of three dose levels of antigen in combination with GSK pandemic adjuvant, as well as an adjuvant from another undisclosed company.

During the Phase I tests, the Covid-19 vaccine candidate will be given on a one and two-dose vaccination schedule, 21 days apart.

GSK and Medicago expect to complete development and make the vaccine available in the first half of next year, contingent on clinical development and regulatory considerations.

Furthermore, the companies will explore the expansion of their collaboration to create a post-pandemic Covid-19 vaccine candidate and also vaccines for other infectious diseases.

Medicago’s plant-based production platform will be used to manufacture the Covid-19 vaccine antigen. The technology involves the use of plant leaves as bioreactors to generate the S-spike protein that self-assemble into VLPs for the CoVLP vaccine candidate.

In addition, the platform is said to be highly scalable and can allow the manufacture of large quantities of vaccine in a shortened timeline.

The combination of this technology with GSK adjuvant system could help produce around 100 million doses by the end of next year while a large-scale facility being constructed in Quebec City, Canada, is expected to deliver up to one billion doses annually by the end of 2023.

GSK Vaccines chief medical officer Dr Thomas Breuer said: “We strongly believe that multiple vaccines are needed, including post-pandemic vaccines.

“This plant-based technology also shows promise beyond Covid-19 and has the potential to help prevent other infectious diseases.”

Over the past few months, GSK forged multiple partnerships to offer access to its adjuvant system for the development of Covid-19 vaccine candidates, including an alliance with Sanofi.

Related Companies

Free Report
img

Navigate your business through the ‘new normal’

COVID-19 continues to dominate headlines the world over. It has already affected our lives forever. The way we work, shop, eat, seek medical advice, and socialize will all be different in the future. Quite how different remains to be seen, but all industries must plan for multiple eventualities.  Faced with an explosion of conflicting information on how to plan and implement successful recovery strategies, decision-makers are in dire need of a single, reliable source of intelligence.   GlobalData’s COVID-19 Executive Briefing gives you access to unparalleled data and insights to successfully navigate the uncertain road to recovery across the world’s largest industries. Understand every aspect of this disruptive theme by delving into: 
  •  COVID-19 infection update, with statistics on the spread, testing by country, as well as the latest data on vaccines and therapeutic developments 
  • Economic impact overview, covering stock market indices, GDP, unemployment rates, policy responses & GlobalData’s economic recovery scorecards 
  • Sector developments, with access to sector insight summaries, cross-sector indices and the leaders and laggards in each industry vertical 
Whatever your company’s imminent strategic plans, the long-lasting impact of COVID-19 must not be overlooked. Find out how to futureproof your business operations – download our report today. 
by GlobalData
Enter your details here to receive your free Report.

Topics in this article:
NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. A weekly roundup of the latest news and analysis, sent every Friday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy
SUBSCRIBED

THANK YOU