Leucid Bio will use ImaginAb’s CD8 ImmunoPET tracer along with LEU011 in its basket study to treat solid tumours. Credit: National Cancer Institute on Unsplash.

Biotechnology company ImaginAb has entered into a new non-exclusive licence and supply agreement with Leucid Bio for CD8 ImmunoPET technology.

ImaginAb will be responsible for licensing and supplying the clinical doses of 89Zr crefmirlimab berdoxam, its investigational CD8 ImmunoPET tracer, to Leucid Bio.

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Leucid Bio will use the CD8 ImmunoPET tracer along with LEU011 targeting NKG2DL, autologous CAR T-cells, in its basket study to treat solid tumours.

ImaginAb CEO Ian Wilson stated: “We are delighted that Leucid Bio will use our investigational CD8 ImmunoPET for the first time in conjunction with CAR-T therapies.

“This agreement with Leucid Bio is an opportunity for ImaginAb to continue expanding our partnerships, and showcases the increasing adoption of our CD8 ImmunoPET technology.”

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CD8 ImmunoPET (89Zr crefmirlimab berdoxam) is an 89Zr-labeled mini body, designed to bind to CD8 receptors on human T cells for non-invasive, quantitative PET imaging.

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The technique is currently being investigated for diagnosing the immune status of a patient, measuring the efficacy of immunotherapies and predicting patients’ outcomes.

Leucid Bio chief business officer Artin Moussavi said: “This is an exciting partnership for Leucid as this cutting-edge technology will provide evidence of the biodistribution of LEU011 CAR T-cells.

“This will be the first time this technology will be used in a solid tumour CAR-T clinical setting, allowing Leucid to generate data that demonstrate the tracking of LEU011 to tumour sites in the first phase of the trial.

“This data would validate in humans the significant improvements already demonstrated with LEU011 in preclinical studies.”

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