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March 2, 2020updated 02 Mar 2021 5:52pm

Israeli researchers near Covid-19 vaccine development

Scientists at MIGAL Research Institute in Israel expect to start producing a Covid-19 vaccine in the next eight-ten weeks, based on their avian coronavirus Infectious Bronchitis Virus (IBV) vaccine.


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Scientists at MIGAL Research Institute in Israel expect to start producing a Covid-19 vaccine in the next eight-ten weeks, based on their avian coronavirus Infectious Bronchitis Virus (IBV) vaccine.

The team developed the IBV vaccine after four years of research, funded by the country’s Ministry of Science & Technology and conducted in alliance with the Ministry of Agriculture.

IBV is a disease affecting poultry, and the new vaccine was found to be effective in pre-clinical trials at the Volcani Institute.

The researchers discovered a potential Covid-19 vaccine candidate as a by-product of the IBV vaccine. They made genetic alterations to adapt the IBV vaccine to the human strain of the novel coronavirus.

According to research findings, the poultry coronavirus possesses high genetic similarity to Covid-19 and uses the same mechanism for infection.

Currently, the team is working towards approvals for in-vivo testing and the initiation of manufacturing.

MIGAL Galilee Research Institute CEO David Zigdon said: “Given the urgent global need for a human coronavirus vaccine, we are doing everything we can to accelerate development. Our goal is to produce the vaccine during the next eight to ten weeks and to achieve safety approval in 90 days.

“This will be an oral vaccine, making it particularly accessible to the general public. We are currently in intensive discussions with potential partners that can help accelerate the in-human trials phase and expedite the completion of final product development and regulatory activities.”

MIGAL Biotechnology Group leader Dr Chen Katz notes that the vaccine’s scientific framework comes from a new protein expression vector.

The vector forms and generates a chimeric soluble protein, which delivers the viral antigen into mucosal tissues via self-activated endocytosis. This stimulates the body to form antibodies against the virus.

In preclinical studies, oral vaccination was found to trigger high levels of specific anti-IBV antibodies.

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Navigate your business through the ‘new normal’

COVID-19 continues to dominate headlines the world over. It has already affected our lives forever. The way we work, shop, eat, seek medical advice, and socialize will all be different in the future. Quite how different remains to be seen, but all industries must plan for multiple eventualities.  Faced with an explosion of conflicting information on how to plan and implement successful recovery strategies, decision-makers are in dire need of a single, reliable source of intelligence.   GlobalData’s COVID-19 Executive Briefing gives you access to unparalleled data and insights to successfully navigate the uncertain road to recovery across the world’s largest industries. Understand every aspect of this disruptive theme by delving into: 
  •  COVID-19 infection update, with statistics on the spread, testing by country, as well as the latest data on vaccines and therapeutic developments 
  • Economic impact overview, covering stock market indices, GDP, unemployment rates, policy responses & GlobalData’s economic recovery scorecards 
  • Sector developments, with access to sector insight summaries, cross-sector indices and the leaders and laggards in each industry vertical 
Whatever your company’s imminent strategic plans, the long-lasting impact of COVID-19 must not be overlooked. Find out how to futureproof your business operations – download our report today. 
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