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September 22, 2021updated 21 Oct 2021 3:05pm

J&J’s data confirms robust and durable protection of Covid-19 vaccine

Antibody levels increased to 12-fold after four weeks of administering a booster shot of the vaccine, the study showed.

Johnson & Johnson (J&J) has reported the latest data confirming the robust and durable protection provided by its Janssen Covid-19 vaccine.

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The single-shot vaccine is authorised under a US Food and Drug Administration (FDA) Emergency Use Authorization (EUA) for active immunisation to prevent Covid-19 in people aged 18 years and above.

According to results from the largest real-world evidence study of the vaccine reported so far in the US, stable vaccine efficiency of 79% for Covid-19-associated infections and 81% for hospitalisations linked to the disease were observed.

The study conducted from March to July comprised 390,000 individuals who received the vaccine analysed against nearly 1.52 million unvaccinated people.

No indication of a decline in effectiveness over the study period was reported, including when the Delta variant of SARS-CoV-2 was dominant in the US.

Furthermore, these results are in line with the Phase III ENSEMBLE clinical trial, in which the vaccine offered robust protection against severe/critical disease and mortality at a minimum of 28 days after the vaccination.

Overall efficacy of 75% against severe/critical Covid-19 was observed across all age groups and all countries included in the trial.

The efficacy of 74% against severe/critical Covid-19 was reported in the US while 89% and 83% efficacies against hospitalisation and Covid-19-associated mortality, respectively, were noted.

The latest data also demonstrated that protection against Covid-19 rose when a booster dose of the vaccine was administered.

A vaccine booster dose at two months offered 94% protection against Covid-19 in the US, J&J noted.

When used as a booster, the vaccine demonstrated a consistent safety profile and was generally well-tolerated.

In addition, the Phase III ENSEMBLE 2 trial demonstrated that another shot of the vaccine administered 56 days after the first dose, offered complete protection against severe/critical Covid-19 at a minimum of 14 days after the final vaccination.

It also provided 75% and 94% protection against symptomatic moderate to severe/critical Covid-19 worldwide and in the US, respectively.

Antibody levels increased four to six-fold higher than reported after the single shot when a booster shot was administered two months after the first dose.

When a booster was administered six months after the first dose, antibody levels rose nine times in a week and continued to rise to 12-fold higher after four weeks.

J&J Janssen Research and Development (R&D) global head Mathai Mammen said: “Our large real-world evidence and Phase III studies confirm that the single-shot Johnson & Johnson vaccine provides strong and long-lasting protection against Covid-19-related hospitalisations.

“Our single-shot vaccine generates strong immune responses and long-lasting immune memory. And, when a booster of the Johnson & Johnson Covid-19 vaccine is given, the strength of protection against Covid-19 further increases.”

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Navigate your business through the ‘new normal’

COVID-19 continues to dominate headlines the world over. It has already affected our lives forever. The way we work, shop, eat, seek medical advice, and socialize will all be different in the future. Quite how different remains to be seen, but all industries must plan for multiple eventualities.  Faced with an explosion of conflicting information on how to plan and implement successful recovery strategies, decision-makers are in dire need of a single, reliable source of intelligence.   GlobalData’s COVID-19 Executive Briefing gives you access to unparalleled data and insights to successfully navigate the uncertain road to recovery across the world’s largest industries. Understand every aspect of this disruptive theme by delving into: 
  •  COVID-19 infection update, with statistics on the spread, testing by country, as well as the latest data on vaccines and therapeutic developments 
  • Economic impact overview, covering stock market indices, GDP, unemployment rates, policy responses & GlobalData’s economic recovery scorecards 
  • Sector developments, with access to sector insight summaries, cross-sector indices and the leaders and laggards in each industry vertical 
Whatever your company’s imminent strategic plans, the long-lasting impact of COVID-19 must not be overlooked. Find out how to futureproof your business operations – download our report today. 
by GlobalData
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