View all newsletters
Receive our newsletter – data, insights and analysis delivered to you
  1. Analysis
June 17, 2022updated 20 Jun 2022 1:31pm

MD Anderson, Invectys and CTMC partner to develop CAR T cell therapy

Invectys’ researchers and the CTMC team will jointly develop an HLA-G targeted CAR T cell therapy for solid tumours.

The University of Texas MD Anderson Cancer Center, Invectys and the Cell Therapy Manufacturing Center (CTMC) have entered a strategic partnership to co-develop a compliant and mountable process for human leukocyte antigen (HLA)-G targeted chimeric antigen receptor (CAR) T cell therapy to treat solid tumours.

CTMC is a joint venture between MD Anderson and National Resilience.

The partnership will be based on Invectys’s HLA-G platform to progress new CAR T cell therapies until the preclinical development stage with CTMC into initial-phase clinical trials at MD Anderson. 

Furthermore, the alliance will combine the technology of Invectys with the cell therapy development and manufacturing capabilities of CTMC and MD Anderson’s clinical trial knowledge.

CTMC was launched by merging the complementary expertise of the parties to expedite new cell therapies development and production for cancer patients.

The HLA-G molecule is a key modulator of the human immune system that is usually found during pregnancy when it works to offer protection for the foetus from rejection by the immune system of the mother. 

However, it is unusually expressed in cancer, making it a desirable tumour-specific antigen as the tumour cells suppress the innate immune responses of the patient. 

Invectys’ technology is intended to act on and remove HLA-G-expressing tumour cells, thereby lowering these immunosuppressive effects to reactivate the immune system of the patient.

The company’s researchers and the CTMC team will jointly develop a clinical-grade HLA-G targeted CAR T cell therapy for solid tumours that can be manufactured in bulk. 

The latest partnership will aid in progressing the therapeutic to a Phase I clinical trial at MD Anderson.

MD Anderson Investigational Cancer Therapeutics professor Aung Naing said: “Immunotherapies have revolutionised the treatment landscape for cancer, but currently approved treatments are able to overcome immune suppression only in limited groups of patients. 

“This novel HLA-G technology can revitalise immune cells by identifying and killing solid tumour cancer cells, thereby offering the potential to improve treatment outcomes for a wider group of cancer patients.”

In August 2019, MD Anderson and Boehringer Ingelheim partnered to create a joint Virtual Research and Development Center for oncology research.

Cell & Gene Therapy coverage on Pharmaceutical Technology is supported by Cytiva.

Editorial content is independently produced and follows the highest standards of journalistic integrity. Topic sponsors are not involved in the creation of editorial content.

Free Whitepaper
img

Secure the cell therapy supply chain from bench to bedside

The development of cell therapies is changing healthcare, delivering new hope to thousands of patients around the world. The vein-to-vein workflow for these therapies, however, is not without challenges, many of which will increase as we scale up to treat more patients. Download this free guide from Cytiva to learn more about the challenges and risks associated with the cryogenic supply chain for cell therapies, and how supply chain disruptions can best be mitigated.
by Cytiva Thematic

By clicking the Download Free Whitepaper button, you accept the terms and conditions and acknowledge that your data will be used as described in the Cytiva Thematic privacy policy By downloading this Whitepaper, you acknowledge that we may share your information with our white paper partners/sponsors who may contact you directly with information on their products and services.

Visit our privacy policy for more information about our services, how we may use, process and share your personal data, including information on your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Topics in this article:
NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. A weekly roundup of the latest news and analysis, sent every Friday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy
SUBSCRIBED

THANK YOU

Thank you for subscribing to Pharmaceutical Technology