Gilead Sciences has received exclusive worldwide rights to research, develop and commercialise Boehringer Ingelheim‘s novel non-catalytic site integrase inhibitors (NCINIs) for HIV.
Included in the agreement is Boehringer’s BI 224436 lead compound, which has recently been evaluated in a Phase1a dose-escalation study.
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NCINIs work by targeting the component of the virus responsible for viral DNA’s incorporation in the human genome, inhibiting HIV integrase by binding it to a novel site.
Under the terms of the agreement, Boehringer will receive an upfront payment and could also receive additional milestone payments based on development, regulatory and commercial advancements.
