Phase III data showed that AbbVie’s Aquipta offered a substantial decline in mean monthly migraine days from baseline to 12 weeks. Credit: baranq/Shutterstock.com.

The UK Medicines and Healthcare products Regulatory Agency (MHRA) has granted marketing authorisation for AbbVie’s Aquipta (atogepant) for the prophylaxis of migraine in adults.

Aquipta is an oral calcitonin gene-related peptide receptor antagonist and is indicated for use once a day in patients with a minimum of four migraine episodes in a month.

Go deeper with GlobalData

Premium Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

The latest development is based on data from two Phase III clinical trials, ADVANCE and PROGRESS, which assessed a 60mg once-a-day dose of atogepant in adults with episodic and chronic migraine, respectively.

Trial data showed that Aquipta offered a substantial decline in mean monthly migraine days from baseline to 12 weeks.

The treatment also provided decline from baseline in mean monthly headache days and acute medication days. 

See Also:

In the trials, Atogepant was found to be well tolerated without any serious adverse events reported. Constipation, nausea and fatigue were the most frequently observed adverse reactions in trial subjects.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

AbbVie UK medical director Belinda Byrne said: “There is a common misconception that migraine is ‘just a headache’, but for many patients migraine has a devastating impact on their everyday life.

“AbbVie is committed to advancing the standards of care for people living with migraine and we are delighted that the MHRA has provided marketing authorisation for this new medication. We are currently working with the regulatory authorities to bring this potential treatment to eligible patients as soon as possible.”

In August 2023, the company received approval from the European Commission for Aquipta for the same indication for use in the EU.