View all newsletters
Receive our newsletter – data, insights and analysis delivered to you

Vaxart’s oral vaccine candidate triggers immune response in Covid-19 trial

Vaxart has reported preliminary data from its Phase I study that showed its oral Covid-19 tablet vaccine candidate, VXA-CoV2-1, triggered multiple immune responses against SARS-CoV-2 antigens.

By Vishnu Priyan

Vaxart has reported preliminary data from its Phase I study that showed its oral Covid-19 tablet vaccine candidate, VXA-CoV2-1, triggered multiple immune responses against SARS-CoV-2 antigens.

It proved generally well-tolerated and immunogenic as measured by multiple markers of an immune response to the antigens.

The study is assessing the safety and immunogenicity of VXA-CoV2-1 vaccine with multiple dosing schedules.

In the study, subjects were divided into three cohorts. The first cohort had five participants given two low doses of vaccine 29 days apart.

The remaining cohorts had 15 participants each, who received either single low or high dose of the vaccine.

According to preliminary results from a pooled analysis of all cohorts, VXA-CoV2-1 also triggered immune responses against antigens including CD8+ cytotoxic T-cell response to the viral Spike (S) protein.

Researchers also observed a high percentage in plasmablast cell number, an upregulation of the mucosal homing receptor, as well as an increase in proinflammatory Th1 cytokines.

In addition, data showed that IgA responses in serum and / or nasal swab samples were observed in all of two dose subjects.

Vaxart CEO Andrei Floroiu said: “Our Phase I results highlight the importance of our differentiated vaccine design, as they suggest VXA-CoV2-1 could have broad activity against existing and future coronavirus strains.

“These results are timely, as we are seeing the emergence of new variants less responsive to first-generation vaccines, thus making potential cross-reactivity another important advantage of next-generation vaccines.”

Last March, Emergent BioSolutions agreed to provide molecule-to-market contract development and manufacturing (CDMO) services for Vaxart’s oral vaccine candidate against Covid-19 coronavirus infection.

In a separate development, Enlivex Therapeutics reported positive top-line results from an investigator-initiated Phase II clinical trial of Allocetra in severe and critical Covid-19 patients.

In the trial, 16 Covid-19 patients received off-the-shelf cell therapy Allocetra. Results showed that 87.5% of patients recovered from their severe / critical condition and were discharged from the hospital after an average of 5.3 days on receiving the Allocetra treatment.

Separately, AuraVax Therapeutics entered into an exclusive license agreement with the University of Houston (UH) in the US regarding the intellectual property covering a new intranasal vaccine and STING agonist technologies.

The transaction supports the development of AuraVax’s lead Covid-19 intranasal programme in addition to other vaccines and therapeutics for respiratory diseases.

Cell & Gene Therapy Coverage on Pharmaceutical Technology supported by Cytiva.

Editorial content is independently produced and follows the highest standards of journalistic integrity. Topic sponsors are not involved in the creation of editorial content.

Free Whitepaper

Secure the cell therapy supply chain from bench to bedside

The development of cell therapies is changing healthcare, delivering new hope to thousands of patients around the world. The vein-to-vein workflow for these therapies, however, is not without challenges, many of which will increase as we scale up to treat more patients. Download this free guide from Cytiva to learn more about the challenges and risks associated with the cryogenic supply chain for cell therapies, and how supply chain disruptions can best be mitigated.
by Cytiva Thematic

By clicking the Download Free Whitepaper button, you accept the terms and conditions and acknowledge that your data will be used as described in the Cytiva Thematic privacy policy By downloading this Whitepaper, you acknowledge that we may share your information with our white paper partners/sponsors who may contact you directly with information on their products and services.

Visit our privacy policy for more information about our services, how we may use, process and share your personal data, including information on your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. A weekly roundup of the latest news and analysis, sent every Friday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy


Thank you for subscribing to Pharmaceutical Technology