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Gamlen Instruments|8 February 2017

Gamlen Controlled Humidity Environment

For tableting researchers working with moisture sensitive products, such as effervescent products or biologicals, Gamlen Tableting supplies the Gamlen controlled humidity environment.

Controlled Humidity Environment

For tableting researchers working with moisture sensitive products, such as effervescent products or biologicals, Gamlen Tableting supplies the Gamlen controlled humidity environment.

This environment combines a humidity generator with a glove box system containing either a Gamlen R or D series instrument. Operating between 5% and 90% humidity, the environment is ideal for formulation and process development, quality by design (QbD) for tablets and quality control (QC) of incoming active pharmaceutical ingredients (API) and excipients, as well as material characterisation and pre-formulation.

Key features

Operation of the environment room is simple. Samples are equilibrated in the environment, weighed, compacted using the Gamlen R or D series in compaction mode, then tested in the Gamlen R or D series fracture mode to determine tablet fracture stress.

Gamlen presents a study conducted by V. Penkavova1, L. Kulaviak1, M.C. Ruzicka1, M. Puncochar, and P. Zamostny on the 'Beaking of Anisotropic Rod-Saped Particles'.
The efficiency of downstream processing of active pharmaceutical ingredients (API) can depend on their particulate properties, including size and shape.
This whitepaper described a method for performing dynamic powder compaction analysis and for measuring tensile fracture strength of tablets.
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