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Grace|8 September 2022

Drug Delivery Technology: SILSOL® Silica

Our SILSOL® silica active ingredient delivery technology combines Grace’s extensive expertise in mesoporous silica gel, novel application methods, and patented technologies to accelerate the screening and development of solubility-enhancing solid dispersions, with the added benefit of doing so with compendial, scalable, and available silicas.

Our SILSOL® silica active ingredient delivery technology combines Grace’s extensive expertise in mesoporous silica gel, novel application methods, and patented technologies to accelerate the screening and development of solubility-enhancing solid dispersions, with the added benefit of doing so with compendial, scalable, and available silicas.

The patented technology offers several benefits, including:

  • Enhanced bioavailability through delivery of the amorphous form of active ingredients
  • Sustained stability from amorphous solid dispersions that prevent crystallization/re-crystallization
  • Pharmacopoeia acceptance of our cGMP manufactured silica that conforms to global monographs
  • Scalable cGMP excipient manufacturing from tons to quantities
  • EU Commission Regulation No. 231/2012 (E 551 materials listed on the FDA inactive ingredient database (IID))

Download this free white paper to learn more about our capabilities in custom fine chemicals, purification/chromatographic resins, and formulation/multifunctional excipients.
Grace Fine Chemical Manufacturing Services (FCMS) is a premier, US-based CDMO specialising in small molecule chemistry, including custom APIs, cGMP intermediates and RSMs.
SYLOID® FP silica’s unique, innovative design combines adsorption capacity, particle size, density and internal surface area to provide multifunctional benefits or optimise an application.
To achieve a solid dosage form with liquid ingredients, a porous carrier is needed that can absorb the liquids and be conveniently processed into desirable solid...
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