Polymun Scientific - Biopharmaceutical, Liposomes and Liposomal Manufacturing and Contract Development

Polymun Scientific GmbH is a family-owned company in Vienna, Austria, founded in 1992. Our core activities are contract development and manufacturing of biopharmaceuticals as well as creating liposomal formats of drugs for contract partners.

The revenues are invested in own R&D projects and the further development of technology platforms. Polymun operates in accordance with current GMP guidelines and holds an Austrian production license thus meeting all EU requirements for drug manufacturing.

Polymun employs a team of about 40 dynamic and highly qualified scientists, technologists and support staff. 45% hold an academic title, about 50% have graduated from technical schools or colleges. With quality and reliability as a pre-requisite basis, innovation and creativity are strongly encouraged at Polymun. We are a flexible partner focused on the requirements of our clients.

Biopharmaceuticals

The core competence of Polymun is the development and GMP-compliant manufacture of biopharmaceuticals, using both mammalian and microbial cell technology. Polymun offers all steps from the gene to clinical grade material for innovator and generic products.

We see vector, production cell line, cell banking, processes for fermentation and purification as well as analytical methods as parts of a networked development in order to achieve optimal results. Entirely new projects as well as missing elements of existing processes can be custom designed.

Each step can be operated with protein-free cryopreservation and cell culture media. Polymun has gathered experience in designing purification processes for proteins of all kinds - antibodies, hormones and enzymes. A wide range of analytical methods is available and can be readily adapted to new requirements. GMP-compliance and industrial applicability are central to all operations.

Contract manufacturing includes the preparation of IMPD and CMC documents. Based on our own experience we are able to support planning of phase I-III clinical trials.

As small, independent and private company Polymun has no conflict of interests thus granting a high degree of flexibility and security for its clients including the possibility of technology transfer.

Capacity: Mammalian cells

• Stirred tank: 15 l, 200 l, 1750 l
• Ultrasonic cell retention: up to 100 l continuous perfusion culture
• Air lift: 550 l
• Fluidized bed: 30 l carrier volume
• Yeast / bacteria
• Stirred tank: 50 l
• Downstream purification: process systems up to 600 l/h and 6 bar

Liposomal formulations

Liposomes protect, transport and release your drug at the right place and time. By this, a reduced dose achieves better efficacy and avoids side effects by a non-invasive application.

Polymun offers the development of liposomal formulations for all kinds of active pharmaceutical ingredients or substances for cosmetic application. We manufacture GMP-material including all necessary documentation and assist in planning of clinical trials.

License agreements for Polymun’s patented liposome production technology are offered for the respective substance on an exclusive basis. Contracts can be arranged step by step - proof of concept, in-depth analysis, GMP-material production, product license - or all in one. Industrial applicability is the focus throughout each project.

Polymun’s technology enables the industrial realization of pharmaceutical and cosmetic products for liposomal drug formats. The production technology is suitable for a broad range of substances formulated by passive entrapment, active loading or membrane incorporation.

Main characteristics of our technology are:

• Scalability
• Sterility
• Homogeneous, uniform vesicles
• Entrapment of several product classes with high efficiency
• Batch to batch consistency
• Stability due to a mild procedure