White Papers

Stability Characterisation Using Differential Scanning Calorimetry

Malvern Instruments

An important parameter in production, manufacturing, formulation, and long-term storage, protein stability has large effects on biopharmaceutical products and higher stability means for greater profits and less product waste.

Stability Characterisation Using Differential Scanning Calorimetry

How to Boost Profits With Single-Use Powder Transfer

ILC Dover

Many biopharmaceutical manufacturers are implementing single-use containment and transfer of media and buffer materials to prevent feedstock contamination and promote worker safety.

How to Boost Profits With Single-Use Powder Transfer

DF30 Metering Valve Technology Platform for Drug Delivery

Aptar Pharma

Aptar Pharma is one of the leading suppliers of aerosol metering valves, a key sub-system of pressurised metered dose inhalers (pDMI) that enables accurate and repeatable drug dses to be delivered as an aerosol to the patient's airways.

DF30 Metering Valve Technology Platform for Drug Delivery

Case Study: Formulation Prototypes with Increased Solubility and Bioavailability

Catalent

Catalent Pharma provided London-based pharmaceutical company Trio Medicines with three formulation technologies and four prototypes showing improved solubility and bioavailability for an acetyl prodrug of a novel, well-tolerated G-protein coupled rec...

Case Study: Formulation Prototypes with Increased Solubility and Bioavailability

Efficient Synthesis Development

SYSTAG, System Technik AG

It is impossible to imagine operations and development research without keywords, such as quality be design (QbD), design of experiments (DoE) or established parameter ranges (EPR).

Efficient Synthesis Development

High-Voltage Leak Detection for Pharmaceutical Vials, Syringes, and Liquid-Filled Parenteral Products

PTI - Packaging Inspection Systems

The E-Scan 655 is utilises a new class of high-voltage leak detection (HVLD) technology to inspect vials, syringes, and other liquid-filled parenteral products for container closure integrity.

High-Voltage Leak Detection for Pharmaceutical Vials, Syringes, and Liquid-Filled Parenteral Products

Nasal Drug Delivery Devices and Pain Management Systems

Aptar Pharma

Worth an estimated >2bn in 2009, the nasally administered systemic drugs market has an increasing generics sector, is placing greater emphasis on patient compliance and convenience, and is benefitting from an increasingly ageing population.

Nasal Drug Delivery Devices and Pain Management Systems

Case Study: What You Didn't Know About Breakage of Anisotropic Rod-Shaped particles

Gamlen Instruments

Gamlen presents a study conducted by V. Penkavova1, L. Kulaviak1, M.C. Ruzicka1, M. Puncochar, and P. Zamostny on the 'Beaking of Anisotropic Rod-Saped Particles'.

Case Study: What You Didn't Know About Breakage of Anisotropic Rod-Shaped particles

Top Eight Reasons to Update Your DSC Analysis System

Malvern Instruments

Differential Scanning Calorimetry (DSC) data is used to advance stable and developable proteins into the pipeline, while optimising process and formulation conditions to maintain stability between manufacture and storage.

Top Eight Reasons to Update Your DSC Analysis System

Narrowing the Gap Between Active Ingredients and Critical Excipients

Pfanstiehl

The increasing complexity of large molecule and cell-based therapeutics calls for an evolution in our understanding of the impurity and functional contributions of each formulation component.

Narrowing the Gap Between Active Ingredients and Critical Excipients

Closing Characterisation Gap Between API and Formulation Components

Pfanstiehl

This whitepaper will provide an introduction to high-purity carbohydrates often used for applications such as stabilisation, modulation, and cryopreservation, comparing the old paradigm that formulation components are inactive ingredients with limite...

Closing Characterisation Gap Between API and Formulation Components

GP Pharm: Injectable Products for the Urology, Oncology, CNS and CVS Fields

GP Pharm

GP Pharm: Injectable Products for the Urology, Oncology, CNS and CVS Fields

GP Pharm: Injectable Products for the Urology, Oncology, CNS and CVS Fields

Achieving Successful Drug Formulations Using Dynamic Compaction Analysis

Gamlen Instruments

This whitepaper described a method for performing dynamic powder compaction analysis and for measuring tensile fracture strength of tablets.

Achieving Successful Drug Formulations Using Dynamic Compaction Analysis

Calculating Pressure, Pipe Measurement, and Flow Rate Requirements for a Non-Newtonian Fluid

Malvern Instruments

When pumping fluids over long distances, the required pressure, pipe diameter, and flow rate is calculated. For non-Newtonian fluids, it is sufficient to consider them as power law fluids, in terms of processing, due to the shear rates.

Calculating Pressure, Pipe Measurement, and Flow Rate Requirements for a Non-Newtonian Fluid

Case Study: Downstream Processing in Ingredients with High-API Content

Gamlen Instruments

The efficiency of downstream processing of active pharmaceutical ingredients (API) can depend on their particulate properties, including size and shape.

Case Study: Downstream Processing in Ingredients with High-API Content

How Suspension Rheology is Effected by Particle Characteristics

Malvern Instruments

This whitepaper discusses the effects of particle properties on suspension viscosity and rheological behaviour.

How Suspension Rheology is Effected by Particle Characteristics

Achieve Efficient Product Development through Optimising Resources

SYSTAG, System Technik AG

Development departments suffer from a shortage of resources and are often overburdened with administration tasks.

Achieve Efficient Product Development through Optimising Resources

VeriPac UBV Universal Blister Verification

PTI - Packaging Inspection Systems

The VeriPac UBV Leak Detection System is a deterministic non-destructive technology designed specifically for multi-cavity blister packs. The VeriPac UBV utilizes volumetric imaging under vacuum to detect the presence and location of leaks.

VeriPac UBV Universal Blister Verification

How Virtualisation Can Help Electronic Data Retention

Butterworth Laboratories

One of the most discussed topics currently affecting good manufacturing practices (GMP) laboratories, data integrity involves conforming to fundamental elements of quality: attributable, legible, cotemporaneous, original, and accurate (ALCOA). Of the...

How Virtualisation Can Help Electronic Data Retention

Changing Mobile Phases for OMNISEC Result Improvements

Malvern Instruments

In order to fine-tune degradation rates of polymeric products, polylactic and polyglycolic acid are frequently combined to make polylactic-co-glycolic acid (PLGA).

Changing Mobile Phases for OMNISEC Result Improvements

Contamination Control

Dycem

Thousands of cleanrooms, critical areas and controlled environments are protected by Dycem polymeric contamination control mats and flooring, enabling organisations to reduce particle counts by up to 99.9%.

Contamination Control