The pipeline for mantle cell lymphoma (MCL), a subtype of non-Hodgkin’s lymphoma (NHL), is relatively large and dominated by small molecule kinase inhibitors, which represent 37% of the therapies, followed by monoclonal antibodies (24%) and chimeric antigen receptor T-cell (CAR-T) therapy (18%).
The large prominence of CAR-T, a new and innovative therapy type, is due to the successful approvals that CAR-T therapies have garnered in diffuse large B-cell lymphoma (DLBCL), which is both another subtype of NHL and an indication in which Kite’s Yescarta (axicabtagene ciloleucel) and Novartis’ Kymriah (tisagenlecleucel) are already approved. Developers hope CAR-T therapy will be introduced into MCL soon, as Kymriah is already in Phase III development for the indication.
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Other Phase III agents include Celgene’s Revlimid (lenalidomide) and Janssen’s Imbruvica (ibrutinib), both of which are already approved in other NHL subtypes and are seeking label expansion in MCL. Abbvie/Genentech’s Venclexta (Venetoclax) is a Phase III agent that is seeking a first approval in NHL, and is already approved in chronic lymphocytic leukemia (CLL).
The figure below displays the Phase II and III pipeline for MCL.
Picture: Phase II and III Pipeline for Mantle Cell Lymphoma, 2019. Credit: GlobalData.
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