The significant rise in the use of biopharmaceutical and large molecule therapeutics over recent years has made peptides and proteins popular drug discovery targets for the pharmaceutical and biotechnology industries.
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Protein and peptide drugs, particularly antibodies, have high specificities and potencies with low toxicity incidences, which makes them attractive therapeutics for various therapy areas.
Finding suppliers for protein and peptide synthesis and manufacturing
Pharmaceutical Technology has listed some of the leading providers and suppliers of protein and peptide synthesis and manufacturing, based on its intel, insights, and decades of experience in the sector.
The companies offer services and products such as custom peptide synthesis, peptide libraries and reagents, protected amino acids, unnatural amino acids and derivatives, active pharmaceutical ingredients (APIs) production, and good manufacturing practice (GMP) manufacturing.
The information in the download document is intended for pharmaceutical executives, research scientists, associates, chemists, business development managers, and other individuals involved in protein and peptide synthesis and manufacturing operations within the pharmaceutical industry.
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Protein synthesis and manufacturing techniques
Biotech drug manufacturing is a complex and time-consuming process. rDNA and hybridoma cell technologies allow for mass production of protein-based drugs, making the processes more cost-effective. Despite this, the contamination removal processes for protein biological synthesis make it a more complicated and costly process than peptide synthesis.
In hybridoma cell technology, the fusion of certain white blood cells with hybridomas allows them to be replicated infinitely to produce monoclonal antibody protein-based therapies for the treatment of cancer and other diseases.
In rDNA technology, genes that encode for the required protein are transferred from one cell or organism to another, enabling bulk production of protein-based drugs.
Custom protein synthesis enables fast expression and purification of any protein as required. Pharmaceutical companies providing custom protein production services also offer bulk production of proteins for industrial projects.
Peptide manufacturing
Peptides are manufactured by solid-phase synthesis, solution-phase synthesis, and a combination of both. Solid-phase synthesis is a relatively simple technique that allows rapid production and easy upscaling. Solution-phase peptide synthesis is more suitable for shorter peptide chains, while solid-phase synthesis is better-suited to longer and more complex amino acid sequences.
Peptides are used to design new enzymes, drugs and vaccines. Improvements in their production methods have made peptide synthesis more feasible for general research purposes.