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  1. Comment
December 9, 2021updated 07 Jan 2022 5:41am

Aerami’s upcoming merger with FoxWayne will bolster the company’s PAH portfolio

Proceeds from Aerami’s merger with FoxWayne will help advance the development of the company’s PAH therapy, AER-901 (imatinib).

By GlobalData Healthcare

On 7 December, Aerami Therapeutics announced its plans to enter a business combination agreement with FoxWayne Enterprises Acquisition. Once the deal is completed, the combined companies will operate as Aerami Therapeutics Holdings. GlobalData believes that this merger will be a significant opportunity for Aerami to bolster its pulmonary arterial hypertension (PAH) drug portfolio, as the deal transaction proceeds will help advance the development of AER-901 (imatinib).

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What’s missing from your IPO industry assessment?

IPO activity all but stopped in 2020, as the investment community grew wary of the effects of COVID-19 on economies. No matter how deserving a business was of flotation, momentum was halted by concerns of when a ‘new normal’ of working patterns and trade would set in. Recently, sentiment has changed. Flotations picked up again during the second half of 2021, and now in 2022 the mood is decidedly optimistic. Business leaders have their eyes on fast rebounding economies, buoyant market indices and the opportunity once again to take their businesses public. As a result, global IPOs are expected to hit back this year. With GlobalData’s new whitepaper, ‘IPOs in Consumer and Retail: 5 must-include elements for your prospectus industry report’, you can explore exactly what is needed in the essential literature. GlobalData’s focus lies in the critical areas to get right:
  • Macroeconomic and demographic environment
  • Consumer context
  • Industry environment
  • Competitive environment
  • Route to market
Interested to learn more about what to include in your IPO Industry Assessment report? Download our free whitepaper.
by GlobalData
Enter your details here to receive your free Report.

Despite the availability of multiple treatment options on the market—such as endothelin receptor antagonists (ERAs), PDE5 inhibitors, soluble guanylyl cyclase (sGC) stimulators and prostacyclin derivatives—PAH remains a largely incurable and fatal cardiopulmonary disease. At present, Aerami’s pipeline features a PAH drug candidate, namely imatinib, an inhaled, nebulised formulation of imatinib, currently in Phase I for PAH. Imatinib is a small molecule tyrosine kinase inhibitor (TKI) that blocks signalling by binding to the ATP-binding pocket necessary for receptor activation. Key opinion leaders (KOLs) interviewed by GlobalData have emphasised that they would like to see the development of TKIs because they act on the pathogenic mechanism of PAH. KOLs also said that there is a significant unmet need for a novel drug that works similarly to an anti-cancer drug and can suppress cell growth in the same way as a TKI.

Acquisitions and licensing agreements are a common trend in the PAH disease space. Under the agreement, Aerami Therapeutics Holdings aims to advance in the inhaled therapies space, focusing on respiratory and chronic diseases. The deal will involve FoxWayne issuing millions of shares of its common stock, equivalent to around $250m.

PAH patients often progress and die on triple therapy or have to go into transplant, so targeting a fourth pathway may offer an advantage for the drug. Through this merger, Aerami will have a significant opportunity to maximise the commercial potential of imatinib in the PAH space. Imatinib is expected to advance into a Phase II/III clinical trial for PAH next year.

Related Companies

Free Report
img

What’s missing from your IPO industry assessment?

IPO activity all but stopped in 2020, as the investment community grew wary of the effects of COVID-19 on economies. No matter how deserving a business was of flotation, momentum was halted by concerns of when a ‘new normal’ of working patterns and trade would set in. Recently, sentiment has changed. Flotations picked up again during the second half of 2021, and now in 2022 the mood is decidedly optimistic. Business leaders have their eyes on fast rebounding economies, buoyant market indices and the opportunity once again to take their businesses public. As a result, global IPOs are expected to hit back this year. With GlobalData’s new whitepaper, ‘IPOs in Consumer and Retail: 5 must-include elements for your prospectus industry report’, you can explore exactly what is needed in the essential literature. GlobalData’s focus lies in the critical areas to get right:
  • Macroeconomic and demographic environment
  • Consumer context
  • Industry environment
  • Competitive environment
  • Route to market
Interested to learn more about what to include in your IPO Industry Assessment report? Download our free whitepaper.
by GlobalData
Enter your details here to receive your free Report.

  1. Comment
December 9, 2021

Aerami’s upcoming merger with FoxWayne will bolster the company’s PAH portfolio

Proceeds from Aerami’s merger with FoxWayne will help advance the development of the company’s PAH therapy, AER-901 (imatinib).

By GlobalData Healthcare

On 7 December, Aerami Therapeutics announced its plans to enter a business combination agreement with FoxWayne Enterprises Acquisition. Once the deal is completed, the combined companies will operate as Aerami Therapeutics Holdings. GlobalData believes that this merger will be a significant opportunity for Aerami to bolster its pulmonary arterial hypertension (PAH) drug portfolio, as the deal transaction proceeds will help advance the development of AER-901 (imatinib).

Free Report
img

Understand M&A activity across regions & sectors

Irrespective of market conditions, Mergers and Acquisitions continue to be on the table for global corporations. This was strongly evident when M&A volumes were relatively resilient to the disruption brought on by COVID-19, with only a slight decline in 2020 followed by a strong rebound in 2021. GlobalData's review provides you with insights on M&A trends, highlighting how deal activity shifts across key regions and industries. The deal types covered in our report include:
  • Mergers
  • Acquisitions
  • Asset transactions
  • Private equity buyouts
  • Mergers
  • Acquisitions
  • Asset transactions
  • Private equity buyouts
  • Mergers
  • Acquisitions
  • Asset transactions
  • Private equity buyouts
by GlobalData
Enter your details here to receive your free Report.

Despite the availability of multiple treatment options on the market—such as endothelin receptor antagonists (ERAs), PDE5 inhibitors, soluble guanylyl cyclase (sGC) stimulators and prostacyclin derivatives—PAH remains a largely incurable and fatal cardiopulmonary disease. At present, Aerami’s pipeline features a PAH drug candidate, namely imatinib, an inhaled, nebulised formulation of imatinib, currently in Phase I for PAH. Imatinib is a small molecule tyrosine kinase inhibitor (TKI) that blocks signalling by binding to the ATP-binding pocket necessary for receptor activation. Key opinion leaders (KOLs) interviewed by GlobalData have emphasised that they would like to see the development of TKIs because they act on the pathogenic mechanism of PAH. KOLs also said that there is a significant unmet need for a novel drug that works similarly to an anti-cancer drug and can suppress cell growth in the same way as a TKI.

Acquisitions and licensing agreements are a common trend in the PAH disease space. Under the agreement, Aerami Therapeutics Holdings aims to advance in the inhaled therapies space, focusing on respiratory and chronic diseases. The deal will involve FoxWayne issuing millions of shares of its common stock, equivalent to around $250m.

PAH patients often progress and die on triple therapy or have to go into transplant, so targeting a fourth pathway may offer an advantage for the drug. Through this merger, Aerami will have a significant opportunity to maximise the commercial potential of imatinib in the PAH space. Imatinib is expected to advance into a Phase II/III clinical trial for PAH next year.

Related Companies

Free Report
img

Understand M&A activity across regions & sectors

Irrespective of market conditions, Mergers and Acquisitions continue to be on the table for global corporations. This was strongly evident when M&A volumes were relatively resilient to the disruption brought on by COVID-19, with only a slight decline in 2020 followed by a strong rebound in 2021. GlobalData's review provides you with insights on M&A trends, highlighting how deal activity shifts across key regions and industries. The deal types covered in our report include:
  • Mergers
  • Acquisitions
  • Asset transactions
  • Private equity buyouts
  • Mergers
  • Acquisitions
  • Asset transactions
  • Private equity buyouts
  • Mergers
  • Acquisitions
  • Asset transactions
  • Private equity buyouts
by GlobalData
Enter your details here to receive your free Report.

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