Thermogravimetric Analysis Instruments
Our high-performance thermogravimetric analysis instruments include TG 209 F1 Nevio and TG 209 F3 Nevio.
Thermal Analysis Techniques and Rheometers for the Pharmaceutical Industry
Gebrüder-Netzsch-Straße 19,
95100 Selb,
Germany
The NETZSCH Group is an owner-managed, global technology company headquartered in Germany, specialising in thermal analysis techniques and rheometers for the pharmaceutical industry.
Our Pumps & Systems, Analyzing & Testing, and Grinding & Dispersing business units encompass more than 3,700 employees across 36 countries, as well as a global sales and service network while ensuring client proximity and high-quality service.
The Analyzing & Testing Business Unit portfolio includes conventional thermal analysis instruments such as thermomechanical analysers (TMAs) and thermogravimetric analysers (TGAs), differential scanning calorimeters, adiabatic calorimeters (including accelerating rate calorimeters), instruments for thermophysical properties testing, and newly introduced rheometers.
Rheology is the study of flow and deformation of constituents under applied forces, typically measured using a rheometer, applicable to all materials from fluid dispersions such as nasal sprays, oral medicines and subcutaneous formulations for injection to semi-solids such as adhesive dressings, pastes and topical creams.
Rheometer methods are included in European Pharmacopoeia (Ph Eur) and US Pharmacopoeia (USP).
Differential Scanning Calorimetry (DSC)
Differential Scanning Calorimetry (DSC) is the most universally utilised thermal analysis method for pharmaceutical applications and, along with thermogravimetric analysis, is also stated in various pharmacopoeias, such as Japanese Pharmacopoeia (JP), Ph Eur and USP.
Classic application areas include:
Thermogravimetry (TG) or thermogravimetric analysis (TGA)
Thermogravimetry measures the mass transformation of substances during heating. Furthermore, the coupling of a thermobalance to a gas analysing system such as Fourier Transform Infrared (FTIR), mass spectrometry (MS) or gas chromatography-mass spectrometry (GCMS) ensures identification of evolved gases, helping to elucidate the process behind mass changes.
TGA instruments can be applied to the study of:
Thermogravimetry is also a popular method for regulating loss on drying in numerous monographs.
Through kinetic evaluation with our NETZSCH Kinetics Neo, predictions concerning stability based on thermoanalytical measurements can be calculated to allow for reports that would otherwise experimentally be unreachable or only at high disbursement.
Simultaneous differential scanning calorimetry – thermogravimetry (STA) instruments
‘STA’ stands for the concurrent application of DSC and TGA to a particular sample under matching measurement conditions, unfolding its advantages concerning:
To gather information regarding the safety of new or existing production process, accelerating rate calorimeters (ARCs), typically in combination with DSC instruments and the Thermal Simulations/Kinetics Neo software packages, can be used to identify thermal hazards, as well as mimic worst-case scenarios.
An ARC is an adiabatic calorimeter, which monitors runaway reactions, or exothermal events, as well as changes in pressure while the sample is heated.
NETZSCH prides itself in high-performance standards, promising our clients exceptional performance in all we do, proven since 1873.
Our applications experience includes more than five decades in the Analyzing & Testing business unit, a comprehensive and contemporary product line, and inclusive service offerings guarantee that our solutions will not only meet every requirement but also exceed every expectation.
Our high-performance thermogravimetric analysis instruments include TG 209 F1 Nevio and TG 209 F3 Nevio.
The Kinexus DSR and DSR+ rheometers are a dynamic shear rheometer developed for routine analysis and quality control (QC) testing in the asphalt industry, with true ‘plug and play’ functionality for all measuring systems and environmental control units.
NETZSCH develops a range of capillary rheometers.
NETZSCH manufactures a vast array of modular rheometers.
Our differential scanning calorimetry (DSC) products include premium instruments for research and development, material characterization and contract testing.
Early high cultures already used willow bark as a remedy for fever and pain [1]; the Roman scholar, Plinius the Elder, regarded willow bark as a medicine and the Teutons and Celts produced extracts by cooking willow bark, the ingredients of which were chemically related to synthetic acetylsalicylic acid [2].
Standard ASTM E2550 describes the thermal stability of a material as the “temperature at which the material starts to decompose or react and the extent of mass change using thermogravimetry”.
Thermogravimetry (TGA) is frequently applied for the compositional analyses of such materials as, for example, fibre-reinforced polymer composites. The residual mass at the end of a TGA experiment reflects the filler or glass fibre content, as well as the presence of impurities.
The NETZSCH Database for Curve Recognition and Comparison of Measurement Curves It is possible to identify substances manually by comparing their characteristic data with literature sources or with previous measurements, but it is far more effective to automatise this process and to use databases for comparison purpose.
Did you out on any of our rheology webinars the took place earlier this year? Watch them now for free!
For development, research and quality control of excipients, active pharmaceutical ingredients (APIs), and formulations, Thermal Analysis offers effective analytical methods.
Gebrüder-Netzsch-Straße 19
95100 Selb
Germany