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Technobis Crystallisation Systems

Crystallisation Solutions for Pharmaceutical Companies

Technobis Crystallization Systems provides solutions for solid-state research, process development and formulation.

Pyriestraat 2,
1812 SC Alkmaar,

Technobis Crystallization systems is a world leading technology provider for solid-state research, process development and formulation. Our mission is to help research succeed.

Since 2005, platforms for accelerating crystallization research have been successfully developed and installed in nearly every pharmaceutical research lab in the world. With more than 500 units in the field, a large community of scientists have been enabled to make a significant contribution to the accelerated development of new pharmaceuticals.

In the last few years, new applications have been developed in agrochemical, fine chemical, military and (bio) fuel research, food and personal care creating new markets focused on understanding the importance of crystallization research.

Our workflow consists of:

  • The CrystalBreeder® is the first crystallizer dedicated for both development and discovery, carrying out complete crystallization screens with as little as 1mg of sample.
  • The Crystal16® parallel crystallizer is a multiple reactor station providing a screening solution for solubility determination, solid-state research and process development: medium-throughput crystallization studies at a 1ml scale.
  • With eight independently controlled reactors and additional analytical capabilities, the Crystalline® is a unique modular product line at a working volume of 5ml for solid-state research, process development and formulation research.

Real-time turbidity measurements

Enhance your early stage solid state screening with the CrystalBreeder bench-top system.

The CrystalBreeder takes the guesswork out of solid-state screening. It is the next generation multi-reactor crystallization platform for medium-throughput solid-state research, operating at a working volume of 0.05-0.25ml.

Carry out rapid crystallization screens with 100 mg of sample using multiple crystallization modes, including:

  • Cooling crystallization
  • Evaporation crystallization
  • Vapor diffusion crystallization
  • Slurry
  • Thermocycling

Solubility and solid-state reserach

Improve and accelerate your crystallization screening with the Crystal16 parallel crystallizer.

The ultimate instrument for research and process development. With 16 reactors at a volume of 1mL, easily determine solubility curves and screen for crystallization conditions. Experience the tool being used by over 500 crystallization chemists.

The technology for a wide range of applications:

  • Solubility determination
  • Phase diagrams
  • Chiral separation
  • Polymorph, Salt and Co-Crystal screening
  • Amorphous solid dispersions

Crystallisation and formulation analysis

Access crystallization and formulation information at ml scale with the Crystalline series.

The Crystalline with through the vial analytical capabilities like turbidity, particle visualization or Raman is easy to set up and operate. No insert probes into reaction vessel! No cross contamination!

The Crystalline combines temperature and turbidity measurements with real time particle imaging. Seeing what is happening in the vial has never been easier.

  • Visualization of the crystallization or formulation processes
  • Real time particle size (PSD) and shape information at mL scale

Technobis Crystalline

Access crystallization and formulation information at mL scale with the Crystalline series.

Technobis Brand Video

Technobis Crystallization Systems provides solutions for solid-state research, process development and formulation.

Measuring Secondary Nucleation through a Single Crystal Seeding Approach

Crystallization is a common process in the pharma industry in the manufacturing of solid form doses. It is a highly complex process consisting of kinetic, thermodynamic and chemical factors that compete against each other making crystallization difficult to control, therefore understanding the steps involved in crystallization is paramount.

Technobis Crystallisation Systems

Pyriestraat 2
1812 SC Alkmaar

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